ArticleJournal of the American Academy of Dermatology2019
Association between itch and cancer in 16,925 patients with pruritus: Experience at a tertiary care center.
Article in Journal of the American Academy of Dermatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- European S2k Guideline on Chronic PruritusActa dermato-venereologica · 2025Guideline
- [Systemic pruritus: focus on hematological, nephrogenic, and hepatobiliary etiologies].Dermatologie (Heidelberg, Germany) · 2026Article
- Modulatory effects of bioactive natural compounds on pruritic pathways: mechanistic basis and therapeutic prospects.Inflammopharmacology · 2025Review
- The frequency of peripheral blood eosinophilia and its clinical significance in patients with dermatomyositis.GHM open · 2025Article
- Enhanced CXCL10 expression in mast cells for cutaneous neurofibroma presenting with pain and itch.British journal of cancer · 2025Article
- Hsa-miR-194-5p and hsa-miR-195-5p are down-regulated expressed in high dysplasia HPV-positive Pap smear samples compared to normal cytology HPV-positive Pap smear samples.BMC infectious diseases · 2024Article
- Article
- "Look Beyond the Skin": A case report about chronic pruritus.SAGE open medical case reports · 2022Article
- Itch: Epidemiology, clinical presentation, and diagnostic workup.Journal of the American Academy of Dermatology · 2022Review
- Pruritus is common in patients with chronic liver disease and is improved by nalfurafine hydrochloride.Scientific reports · 2021Article
- A basophil-neuronal axis promotes itch.Cell · 2021Article
- Emerging Research in Chronic Pruritus: From Bedside to Bench and Back Again.Medicines (Basel, Switzerland) · 2020Article
- Patterns among Patients with Chronic Pruritus: A Retrospective Analysis of 170 Patients.Acta dermato-venereologica · 2020Article
- Comorbidities in Mycosis Fungoides and Racial Differences in Co-Existent Lymphomatoid Papulosis: A Cross-Sectional Study of 580 Patients in an Urban Tertiary Care Center.Medicines (Basel, Switzerland) · 2019Article
- Proteomic and Phosphoproteomic Analysis Reveals that Neurokinin-1 Receptor (NK1R) Blockade with Aprepitant in Human Keratinocytes Activates a Distinct Subdomain of EGFR Signaling: Implications for the Anti-Pruritic Activity of NK1R Antagonists.Medicines (Basel, Switzerland) · 2019Article
- Drugs as a Frequent Cause of Acute Rash in Patients after CD34Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2019Article
- Association between Itch and Cancer in 3836 Pediatric Pruritus Patients at a Tertiary Care Center.Medicines (Basel, Switzerland) · 2019Article
- Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis.Medicines (Basel, Switzerland) · 2019Article
- Pruritus Associated with Commonly Prescribed Medications in a Tertiary Care Center.Medicines (Basel, Switzerland) · 2019Article
- Etiopathogenesis and Current Management of Oncogenic Pruritus - A Narrative Review.Indian journal of dermatologyReview
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundPruritus has been associated with cancer. However, limited data are available on the types of underlying malignancies associated with pruritus.
objectiveWe sought to characterize the association between pruritus and different cancer types, as well as variations by racial group.
methodsCross-sectional study of patients ≥18 years of age seen at the Johns Hopkins Health System during 2013-2017. Patients with pruritus were compared with patients without pruritus. Analyses were stratified by race.
resultsPatients with pruritus were more likely to have concomitant malignancy than those without pruritus (odds ratio 5.76, 95% confidence interval 5.53-6.00). Most strongly associated were cancers of the liver, gallbladder and biliary tract, hematopoietic system, and skin. Compared with white patients, black patients more frequently had soft tissue, dermatologic, and hematologic malignancies and less frequently had liver, respiratory, gastrointestinal, and gynecologic malignancies. LIMITATIONS: The cross-sectional design precludes analysis of the temporal association between pruritus and malignancy. The study is limited to a single tertiary care center.
conclusionPruritus is most strongly associated with cancers of the liver, skin, and hematopoietic system. Black patients with pruritus have a higher likelihood of skin, soft tissue, and hematologic malignancies than white patients, while whites have higher likelihoods of liver, respiratory, gastrointestinal, and gynecologic malignancies.
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