Evidence map›Paper›PMID 30217161›Full record

ArticleVirology journal2018

Immunization with a suicidal DNA vaccine expressing the E glycoprotein protects ducklings against duck Tembusu virus.

Jingyu Tang, Zhuangli Bi, Mingyang Ding, Dongdong Yin, Jie Zhu, Li Zhang, Qiuhong Miao, Yingqi Zhu, Guijun Wang, Guangqing Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. The difference in CD4Frontiers in immunology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jingyu TangCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Zhuangli BiCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Mingyang DingShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No. 518 Ziyue Rd, Shanghai, 200241, China.
Dongdong YinCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Jie ZhuShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No. 518 Ziyue Rd, Shanghai, 200241, China.
Li ZhangCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Qiuhong MiaoShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No. 518 Ziyue Rd, Shanghai, 200241, China.
Yingqi ZhuCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Guijun WangCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China. wgj@ahau.edu.cn.
Guangqing LiuShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No. 518 Ziyue Rd, Shanghai, 200241, China. liugq@shvri.ac.cn.
Shanghai Veterinary Research Institute · CNAnhui Agricultural University · CNChinese Academy of Agricultural Sciences · CN

Funding

Chinese Natural Sciences Foundation 31672572, 31270194Foundation of Anhui Province Key Laboratory of Veterinary Pathobiology and Disease Control ZZKT201726Foundation of Shanghai Key Laboratory of Veterinary Biotechnology klab201712key project of Agriculture science and technology of Shanghai 2016043Key Project of Department of Science and Technology in Anhui province 11070303024Key project of educational commission of Anhui province of China KJ2012A124key research project of national science and technology 2016YFD0500108National Key Research & Development Program 2016YFD0500805Natural Science Foundation of Anhui Province (CN) 1508085QC60
6 · The paper itself

Abstract

backgroudDuck Tembusu virus (DTMUV), a pathogenic flavivirus, emerged in China since 2010 and causing huge economic loss in the Chinese poultry industry. Although several vaccines have been reported to control DTMUV disease, few effective vaccines are available and new outbreaks were continuously reported. Thus, it is urgently to develop a new effective vaccine for prevention of this disease.

methodsIn this study, a suicidal DNA vaccine based on a Semliki Forest virus (SFV) replicon and DTMUV E glycoprotein gene was constructed and the efficacy of this new vaccine was assessed according to humoral and cell-mediated immune responses as well as protection against the DTMUV challenge in ducklings.

resultsOur results showed that the recombinant SFV replicon highly expressed E glycoprotein in DEF cells. After intramuscular injection of this new DNA vaccine in ducklings, robust humoral and cellular immune responses were observed in all immunized ducklings. Moreover, all ducklings were protected against challenge with the virulent DTMUV AH-F10 strain.

conclusionsIn conclusion, we demonstrate that this suicidal DNA vaccine is a promising candidate facilitating the prevention of DTMUV infection.

Indexed as

AnimalsChinaDucksFlavivirusFlavivirus InfectionsGenetic VectorsGlycoproteinsImmunity, CellularImmunity, HumoralInjections, IntramuscularPoultry DiseasesSemliki forest virusVaccines, DNAViral Envelope ProteinsViral VaccinesGlycoproteinsVaccines, DNAViral Envelope ProteinsViral VaccinesDucklingsDuck tembusu virusE glycoproteinSuicidal DNA vaccine

Identifiers

PMID30217161
PMCPMC6137926
OpenAlexW2892321541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.