Evidence map›Paper›PMID 30217093›Full record

ReviewViruses2018

Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview.

Ahmed Mostafa, Elsayed M Abdelwhab, Thomas C Mettenleiter, Stephan Pleschka

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
180citing papers in PubMed, 1 pooled it
16.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

180 citing papers in PubMed, 1 synthesis or guideline pooled it, 286 citations in OpenAlex.

  1. Pooled it
  2. A Phase 1/2 Dose-Ranging Safety and Immunogenicity Study of mRNA-Based Candidate Pandemic Influenza Vaccines in Healthy Adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Trial
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Proteomic Analysis of Influenza.Advances in experimental medicine and biology · 2026
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

120 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Ahmed MostafaInstitute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392 Giessen, Germany. Ahmed_elsayed@daad-alumni.de.
Elsayed M AbdelwhabInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, 17493 Greifswald-Insel Riems, Germany. Sayed.Abdel-Whab@fli.de.ORCID 0000-0003-2103-0922
Thomas C MettenleiterInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, 17493 Greifswald-Insel Riems, Germany. thomas.mettenleiter@fli.de.ORCID 0000-0002-8385-7899
Stephan PleschkaInstitute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392 Giessen, Germany. stephan.pleschka@viro.med.uni-giessen.de.
Friedrich-Loeffler-Institut · DEJustus-Liebig-Universität Gießen · DE

Funding

Deutsche Forschungsgemeinschaft AB567/1-2Deutsche Forschungsgemeinschaft SFB 1021Deutsche Forschungsgemeinschaft SFB/TR 84Deutsche Forschungsgemeinschaft VE780/1-1Horizon 2020 DELTA-FLUJustus Liebig Universität Gießen Just'us postdoctoral fellowship
6 · The paper itself

Abstract

Influenza A viruses (IAVs) possess a great zoonotic potential as they are able to infect different avian and mammalian animal hosts, from which they can be transmitted to humans. This is based on the ability of IAV to gradually change their genome by mutation or even reassemble their genome segments during co-infection of the host cell with different IAV strains, resulting in a high genetic diversity. Variants of circulating or newly emerging IAVs continue to trigger global health threats annually for both humans and animals. Here, we provide an introduction on IAVs, highlighting the mechanisms of viral evolution, the host spectrum, and the animal/human interface. Pathogenicity determinants of IAVs in mammals, with special emphasis on newly emerging IAVs with pandemic potential, are discussed. Finally, an overview is provided on various approaches for the prevention of human IAV infections.

Indexed as

AnimalsDrug DiscoveryEvolution, MolecularGenome, ViralGenomicsGeography, MedicalGlobal HealthHost-Pathogen InteractionsHumansInfluenza A virusInfluenza, HumanOrthomyxoviridae InfectionsVirulenceVirulence FactorsZoonosesVirulence FactorsevolutionInfluenza A viruspandemicpathogenicityzoonosis

Identifiers

PMID30217093
PMCPMC6165440
OpenAlexW2891542297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.