Evidence map›Paper›PMID 30217053›Full record

ReviewMolecules (Basel, Switzerland)2018

Natural Peptides in Drug Discovery Targeting Acetylcholinesterase.

Vivitri Prasasty, Muhammad Radifar, Enade Istyastono

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Novel Emerging Targets Identification in Reducing Risk of Alzheimer's Disease.Central nervous system agents in medicinal chemistry · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Recent advances in the development of therapeutic peptides.Trends in pharmacological sciences · 2023
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Hydrolase-Treated Royal Jelly Attenuates HInternational journal of food science · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Vivitri PrasastyFaculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta 12930, Indonesia. vivitri.dewi@atmajaya.ac.id.ORCID 0000-0002-2992-1247
Muhammad RadifarDepartment of Medical Laboratory Technology, Academy of Health Sciences Guna Bangsa, Condongcatur, Depok, Sleman, Yogyakarta 55283, Indonesia. radifar@gunabangsa.ac.id.ORCID 0000-0001-9156-9478
Enade IstyastonoFaculty of Pharmacy, Sanata Dharma University, Paingan, Maguwoharjo, Depok, Sleman, Yogyakarta 55282, Indonesia. enade@usd.ac.id.ORCID 0000-0002-8344-5587
Atma Jaya Catholic University of Indonesia · IDSanata Dharma University · ID

Funding

Kementerian Riset Teknologi Dan Pendidikan Tinggi Republik Indonesia SP DIPA-042.06.01.401516/2018
6 · The paper itself

Abstract

Acetylcholinesterase-inhibitory peptide has gained much importance since it can inhibit acetylcholinesterase (AChE) and increase the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission in pharmacological treatment of Alzheimer's disease (AD). Natural peptides have received considerable attention as biologically important substances as a source of AChE inhibitors. These natural peptides have high potential pharmaceutical and medicinal values due to their bioactivities as neuroprotective and neurodegenerative treatment activities. These peptides have attracted great interest in the pharmaceutical industries, in order to design potential peptides for use in the prophylactic and therapy purposes. Some natural peptides and their derivatives have high commercial values and have succeeded in reaching the pharmaceutical market. A large number of peptides are already in preclinical and clinical pipelines for treatment of various diseases. This review highlights the recent researches on the various natural peptides and future prospects for AD management.

Indexed as

Alzheimer DiseaseAnimalsAquatic OrganismsBiological ProductsCholinesterase InhibitorsDrug DiscoveryHumansPeptidesPlant ExtractsBiological ProductsCholinesterase InhibitorsPeptidesPlant ExtractsacetylcholinesteraseAlzheimer’s diseasedrug discoveryinhibitornatural peptides

Identifiers

PMID30217053
PMCPMC6225273
OpenAlexW2892223780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.