ReviewJournal of clinical medicine2018
The Diagnosis and Clinical Significance of Paragangliomas in Unusual Locations.
Review in Journal of clinical medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 1 synthesis or guideline pooled it, 156 citations in OpenAlex.
- Primary pancreatic paraganglioma: a systematic review.Endocrine · 2026Pooled it
- Case Report: Pancreatic Paraganglioma Mimicking a Well-Differentiated Neuroendocrine Tumor: The Importance of Cytokeratin Immunohistochemistry.Diagnostic cytopathology · 2026Article
- Incidental discovery of a non-secreting bladder paraganglioma: A case report.Urology case reports · 2026Article
- Challenges in peri-aortic paraganglioma management.Journal of surgical case reports · 2026Article
- A Cauda Equina Neuroendocrine Tumor with Tyrosine Hydroxylase Expression.Endocrine pathology · 2026Article
- Double faces of pheochromocytoma and paraganglioma-a review of integrated pathologic diagnosis.Endocrine journal · 2026Review
- The New Tumor Predisposition Syndromes with Neuro-Oncological Relevance-A Comprehensive Review for Neuroradiologists.Clinical neuroradiology · 2026Review
- Paraganglioma of the Spermatic Cord: A Case Report and Literature Review of an Uncommon Entity.Cureus · 2026Article
- Primary Hepatic Paraganglioma Mimicking Hepatocellular Carcinoma: A Diagnostic Challenge and Literature Review.Cureus · 2026Article
- Multicenter evaluation of the PASS score as a negative predictive tool and the impact of inter-observer variability in pheochromocytoma and paraganglioma risk stratification.Journal of pathology and translational medicine · 2026Article
- Non-Functional Paraganglioma of the Urinary Bladder: A Rare Cause of Bladder Tumor.IJU case reports · 2026Article
- [Analysis of misdiagnosis causes of vagal paraganglioma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026Article
- Peptide Receptor Radionucleotide Therapy for Unresectable Paediatric Head and Neck Paraganglioma in Aotearoa New Zealand.Case reports in otolaryngology · 2026Article
- The evolving roles of pathologists in paragangliomas and pheochromocytomas.Virchows Archiv : an international journal of pathology · 2026Review
- MuCoSA: Multi-contextual similarity assessment for histopathology image search.Journal of pathology informatics · 2026Article
- Clinical significance, prognosis, and risk model of SDHB expression loss and ERBB2 expression in pheochromocytoma and paraganglioma.Endocrine connections · 2025Article
- Current Understanding of Carotid Body Paraganglioma Management.Vascular specialist international · 2025Review
- Multiple paragangliomas diagnosed in head, neck, and mediastinum: a case report.Diagnostic pathology · 2025Article
- An Unusual Entity in Urology: Urinary Bladder Paraganglioma.Journal of medical cases · 2025Article
- Familial Paraganglioma Presenting With Acute Coronary Syndrome and Coronary Vasospasm.JCEM case reports · 2025Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paragangliomas are neuroendocrine neoplasms, derived from paraganglia of the sympathetic and parasympathetic nervous systems. They are most commonly identified in the head and neck, being most frequent in the carotid body, followed by jugulotympanic paraganglia, vagal nerve and ganglion nodosum, as well as laryngeal paraganglia. Abdominal sites include the well-known urinary bladder tumors that originate in the Organ of Zuckerkandl. However, other unusual sites of origin include peri-adrenal, para-aortic, inter-aortocaval, and paracaval retroperitoneal sites, as well as tumors in organs where they may not be expected in the differential diagnosis of neuroendocrine neoplasms, such as thyroid, parathyroid, pituitary, gut, pancreas, liver, mesentery, lung, heart and mediastinum. The distinction of these lesions from epithelial neuroendocrine neoplasms is critical for several reasons. Firstly, the determination of clinical and biochemical features is different from that used for epithelial neuroendocrine tumors. Secondly, the genetic implications are different, since paragangliomas/pheochromocytomas have the highest rate of germline susceptibility at almost 40%. Finally, the characterization of metastatic disease is unique in these highly syndromic lesions. In this review, we summarize updated concepts by outlining the spectrum of anatomic locations of paragangliomas, the importance of morphology in establishing the correct diagnosis, the clinical implications for management, and the impact of genetics on the distinction between multifocal primary tumors compared with malignant disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.