Evidence map›Paper›PMID 30217035›Full record

ArticleNutrients2018

An Active Lifestyle Reinforces the Effect of a Healthy Diet on Cognitive Function: A Population-Based Longitudinal Study.

Behnaz Shakersain, Debora Rizzuto, Hui-Xin Wang, Gerd Faxén-Irving, Federica Prinelli, Laura Fratiglioni, Weili Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Behnaz ShakersainAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet/Stockholm University, Widerströmskahuset, plan 10, Tomtebodavägen 18A, 171 65 Solna, Sweden. behnaz.shakersain@ki.se.ORCID 0000-0002-1248-1687
Debora RizzutoAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet/Stockholm University, Widerströmskahuset, plan 10, Tomtebodavägen 18A, 171 65 Solna, Sweden. Debora.Rizzuto@ki.se.
Hui-Xin WangAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet/Stockholm University, Widerströmskahuset, plan 10, Tomtebodavägen 18A, 171 65 Solna, Sweden. huixin.wang@su.se.
Gerd Faxén-IrvingDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 141 57 Huddinge, Sweden. Gerd.Faxen.Irving@ki.se.
Federica PrinelliAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet/Stockholm University, Widerströmskahuset, plan 10, Tomtebodavägen 18A, 171 65 Solna, Sweden. federica.prinelli@ki.se.
Laura FratiglioniAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet/Stockholm University, Widerströmskahuset, plan 10, Tomtebodavägen 18A, 171 65 Solna, Sweden. Laura.Fratiglioni@ki.se.
Weili XuAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet/Stockholm University, Widerströmskahuset, plan 10, Tomtebodavägen 18A, 171 65 Solna, Sweden. weili.xu@ki.se.ORCID 0000-0001-6140-2968

Funding

the Ministry of Health and Social Affairs, Sweden 2004-2017the National Natural Science Foundation of China 81771519Vetenskapsrådet 2017-00981
6 · The paper itself

Abstract

The joint effect of diet and leisure activity on cognitive function remains unknown. We aimed to verify the hypothesis that an active lifestyle reinforces the effect of the Nordic Prudent Dietary Pattern (NPDP) on cognitive function. A total of 2223 dementia-free Swedish adults aged ≥60 with Mini-Mental State Examination (MMSE) scores ≥27 were followed for an average of 6 years. MMSE was tested during follow-ups. Diet was assessed by food frequency questionnaire. The NPDP index was calculated and tertiled (low, moderate, and high adherence). Participation in physical, mental and social activities was trichotomised (low, moderate, and intense). An active lifestyle was defined based on the participation in each activity. Data were analyzed using mixed-effects models. Moderate-to-high adherence to NPDP was associated with a reduced decline in the MMSE score (β: 0.19, 95% Confidence Interval (CI): 0.14⁻0.24). This association became stronger when combined with moderate-to-intense physical (β: 0.34, 95% CI: 0.2⁻0.45), mental (β: 0.29, 95% CI: 0.21⁻0.37), or social (β: 0.27, 95% CI: 0.19⁻0.34) activities. An active lifestyle strengthened the effect of NPDP on cognitive function by two times, and further lowered risk of MMSE decline by 30%. Thus, an active lifestyle reinforces the effect of a healthy diet on preserved cognitive function, and further decreases the risk of cognitive decline.

Indexed as

CognitionDiet, HealthyExerciseHealth BehaviorHealth Knowledge, Attitudes, PracticeAgedAged, 80 and overCognitive AgingFemaleHealthy AgingHumansLongitudinal StudiesMaleMiddle AgedNutritive ValueSwedenactive life stylecognitive functionleisure activitiespopulation-based cohort studythe Nordic Prudent Dietary Pattern

Identifiers

PMID30217035
PMCPMC6163666

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.