Evidence map›Paper›PMID 30216929›Full record

ArticleEpilepsy & behavior : E&B2018

Ripple oscillations in the left temporal neocortex are associated with impaired verbal episodic memory encoding.

Zachary J Waldman, Liliana Camarillo-Rodriguez, Inna Chervenova, Brent Berry, Shoichi Shimamoto, Bahareh Elahian, Michal Kucewicz, Chaitanya Ganne, Xiao-Song He, Leon A Davis and 17 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy & behavior : E&B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 10 institutions in 1 country.

Zachary J WaldmanDept. of Neurology and Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Liliana Camarillo-RodriguezDept. of Neurology and Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Inna ChervenovaDept. of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Brent BerryDept. of Neurology, Mayo Systems Electrophysiology Laboratory (MSEL), Mayo Clinic, Rochester, MN 55905, USA; Dept. of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Shoichi ShimamotoDept. of Neurology and Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Bahareh ElahianDept. of Neurology and Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Michal KucewiczDept. of Neurology, Mayo Systems Electrophysiology Laboratory (MSEL), Mayo Clinic, Rochester, MN 55905, USA; Dept. of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Chaitanya GanneDept. of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Xiao-Song HeDept. of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Leon A DavisDept. of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Joel SteinDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sandhitsu DasPenn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Memory Center, Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Richard GorniakDept. of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Ashwini D SharanDept. of Neurosurgery, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Robert GrossEmory University, Dept. of Neurosurgery, Atlanta, GA 30322, USA.
Cory S InmanEmory University, Dept. of Neurosurgery, Atlanta, GA 30322, USA.
Bradley C LegaUniversity of Texas Southwestern Medical Center, Dept. of Neurosurgery, Dallas, TX 75390, USA.
Kareem ZaghloulSurgical Neurology Branch, NINDS, NIH, Bethesda, MD 20892, USA.
Barbara C JobstDartmouth-Hitchcock Medical Center, Dept. of Neurology, Lebanon, NH 03756, USA.
Katheryn A DavisDept. of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Paul WandaDept. of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mehraneh KhadjevandDept. of Neurology, Mayo Systems Electrophysiology Laboratory (MSEL), Mayo Clinic, Rochester, MN 55905, USA; Dept. of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Joseph TracyDept. of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Daniel S RizzutoDept. of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Gregory WorrellDept. of Neurology, Mayo Systems Electrophysiology Laboratory (MSEL), Mayo Clinic, Rochester, MN 55905, USA; Dept. of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Michael SperlingDept. of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Shennan A WeissDept. of Neurology and Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address: Shennan.Weiss@jefferson.edu.
Thomas Jefferson University · USUniversity of Pennsylvania · USEmory University · USWinnMed · USDartmouth–Hitchcock Medical Center · USMayo Clinic · USMayo Clinic in Florida · USNational Institutes of Health · USPenn Center for AIDS Research · USThe University of Texas Southwestern Medical Center · US

Funding

Investigating the neural mechanisms of human cognitive function through intracranial recordingsZIANS003144 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI ZAGHLOUL, KAREEM · 2014 to 2025
$36.1M
Reducing or obviating the need for chronic intracranial electroencephalogram telemetry for epilepsy surgery patients by utilizing inter-ictal HFO rates: A study of diagnostic accuracyK23NS094633 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI WEISS, SHENNAN A · 2017 to 2018
$335k
NINDS NIH HHS K23 NS094633
6 · The paper itself

Abstract

backgroundWe sought to determine if ripple oscillations (80-120 Hz), detected in intracranial electroencephalogram (iEEG) recordings of patients with epilepsy, correlate with an enhancement or disruption of verbal episodic memory encoding.

methodsWe defined ripple and spike events in depth iEEG recordings during list learning in 107 patients with focal epilepsy. We used logistic regression models (LRMs) to investigate the relationship between the occurrence of ripple and spike events during word presentation and the odds of successful word recall following a distractor epoch and included the seizure onset zone (SOZ) as a covariate in the LRMs.

resultsWe detected events during 58,312 word presentation trials from 7630 unique electrode sites. The probability of ripple on spike (RonS) events was increased in the SOZ (p < 0.04). In the left temporal neocortex, RonS events during word presentation corresponded with a decrease in the odds ratio (OR) of successful recall, however, this effect only met significance in the SOZ (OR of word recall: 0.71, 95% confidence interval (CI): 0.59-0.85, n = 158 events, adaptive Hochberg, p < 0.01). Ripple on oscillation (RonO) events that occurred in the left temporal neocortex non-SOZ also correlated with decreased odds of successful recall (OR: 0.52, 95% CI: 0.34-0.80, n = 140, adaptive Hochberg, p < 0.01). Spikes and RonS that occurred during word presentation in the left middle temporal gyrus (MTG) correlated with the most significant decrease in the odds of successful recall, irrespective of the location of the SOZ (adaptive Hochberg, p < 0.01).

conclusionRipples and spikes generated in the left temporal neocortex are associated with impaired verbal episodic memory encoding. Although physiological and pathological ripple oscillations were not distinguished during cognitive tasks, our results show an association of undifferentiated ripples with impaired encoding. The effect was sometimes specific to regions outside the SOZ, suggesting that widespread effects of epilepsy outside the SOZ may contribute to cognitive impairment.

Indexed as

Memory, EpisodicAdultBrain MappingCognitionElectrocorticographyEpilepsies, PartialFemaleHumansLogistic ModelsMaleMental RecallMiddle AgedNeocortexOdds RatioSeizuresTemporal LobeEpilepsyEpileptiform dischargeHigh-frequency oscillationVerbal memory

Identifiers

PMID30216929
PMCPMC6240385
OpenAlexW2884134863

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.