Observational studyPsychiatry research2018
Insomnia, negative affect, and psychotic experiences: Modelling pathways over time in a clinical observational study.
Observational study in Psychiatry research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Sleep and schizophrenia: From epiphenomenon to treatable causal target.Schizophrenia research · 2020Pooled it
- The Relationship of Early Sleep Improvement With Response to Pharmacotherapy in Unipolar Psychotic Depression.Journal of clinical psychopharmacologyTrial
- Stress and Sleep Dynamics in Young Adults with Psychotic-Like Experiences Across Daily Life.Schizophrenia bulletin · 2026Article
- Differential Effects of Morning Versus Afternoon Accelerated High-Frequency Repetitive Transcranial Magnetic Stimulation on Sleep Outcomes in Hospitalised Patients With Schizophrenia: Retrospective Cohort Study.Actas espanolas de psiquiatria · 2026Article
- The Effects of Acute Sleep Deprivation on Cognitive Control Mechanisms Associated With Hallucinatory Experiences.Journal of sleep research · 2026Article
- Striatum volume and affective symptomatology are associated with sleep in schizophrenia.Journal of psychiatric research · 2026Article
- Sex differences in sleep architecture among patients with severe mental disorders: a polysomnographic study.Frontiers in psychiatry · 2026Article
- Towards an Integrative Account of Potential Mechanisms Mediating the Path From Sleep Dysfunction to Hallucinations.Schizophrenia bulletin · 2025Review
- Sleep and circadian difficulties in schizophrenia: presentations, understanding, and treatment.Psychological medicine · 2025Review
- Bidirectional associations between short sleep duration, insomnia symptoms, and psychotic-like experiences in adolescents.European child & adolescent psychiatry · 2025Article
- Neurocognitive consequences of adolescent sleep disruptions and their relationship to psychosis vulnerability: a longitudinal cohort study.Npj mental health research · 2024Article
- The dynamic relationship between sleep and psychotic experiences across the early stages of the psychosis continuum.Psychological medicine · 2023Article
- The relationship between internet gaming disorder and psychotic experiences: cyberbullying and insomnia severity as mediators.BMC psychiatry · 2023Article
- Machine learning techniques in diagnostics and prediction of the clinical features of schizophrenia: a narrative review.Consortium psychiatricum · 2023Review
- Sleep disorders predict the 1-year onset, persistence, but not remission of psychotic experiences in preadolescence: a longitudinal analysis of the ABCD cohort data.European child & adolescent psychiatry · 2023Article
- Insomnia and distress as mediators on the relationship from cyber-victimization to self-reported psychotic experiences: a binational study from Tunisia and Lebanon.BMC psychiatry · 2023Article
- Mediation effect of insomnia symptoms between positive psychotic like experiences and suicidal ideation among Lebanese young adults.BMC psychiatry · 2023Article
- Listening to and Believing Derogatory and Threatening Voices.Schizophrenia bulletin · 2023Article
- Sleep as a Mediator Between Cannabis Use and Psychosis Vulnerability: A Longitudinal Cohort Study.Schizophrenia bulletin open · 2023Article
- A novel smartphone-based intervention targeting sleep difficulties in individuals experiencing psychosis: A feasibility and acceptability evaluation.Psychology and psychotherapy · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Insomnia has been shown to contribute to the development of psychotic experiences, predominantly via increasing negative affect. However, the role of insomnia in the persistence of psychotic experiences is yet to be investigated in a clinical population. Furthermore, other plausible influences, such as psychotic experiences contributing to insomnia, remain to be evaluated. This study tests the role of insomnia as a predictor of persistence of psychotic experiences versus other potential causal routes. Twenty-nine patients aged 18-30 with non-affective psychosis completed three assessments over three months of their insomnia, negative affect, and psychotic experiences. Mixed effect models allowed comparisons between hypothesis-based models (comprising insomnia as predictor, negative affect as mediator, and psychotic experiences as outcome) and oppositional models, where relationships were reversed. The results supported the hypothesised mediation model above models where negative affect was primary. Insomnia was also found to be a stronger predictor of later hallucinations than vice versa, although a bidirectional relationship was indicated between insomnia and paranoia. In conclusion, insomnia predicts persistence of psychotic experiences over time to the same or greater extent than psychotic experiences contribute to insomnia. This supports insomnia as a potential intervention target in psychosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.