Evidence map›Paper›PMID 30216541›Full record

SynthesisMovement disorders : official journal of the Movement Disorder Society2018

Detecting Mild Cognitive Deficits in Parkinson's Disease: Comparison of Neuropsychological Tests.

Jeroen Hoogland, Lennard L van Wanrooij, Judith A Boel, Jennifer G Goldman, Glenn T Stebbins, John C Dalrymple-Alford, Connie Marras, Charles H Adler, Carme Junque, Kenn F Pedersen and 19 more

Open access · greenAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Movement disorders : official journal of the Movement Disorder Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.

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  9. Psychometrics and diagnostics of the Italian version of the Alternate Verbal Fluency Battery (AVFB) in non-demented Parkinson's disease patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
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  12. Prodromal dementia with Lewy bodies in REM sleep behavior disorder: A multicenter study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 20 institutions in 11 countries.

Jeroen HooglandDepartment of Neurology, Academic Medical Center Amsterdam, The Netherlands.
Lennard L van WanrooijDepartment of Neurology, Academic Medical Center Amsterdam, The Netherlands.
Judith A BoelDepartment of Neurology, Academic Medical Center Amsterdam, The Netherlands.
Jennifer G GoldmanDepartment of Neurological Sciences, Section of Parkinson Disease and Movement Disorders, Rush University Medical Center, Chicago, Illinois, USA.
Glenn T StebbinsDepartment of Neurological Sciences, Section of Parkinson Disease and Movement Disorders, Rush University Medical Center, Chicago, Illinois, USA.
John C Dalrymple-AlfordNew Zealand Brain Research Institute, Brain Research New Zealand - Rangahau Roro Aotearoa, Christchurch, New Zealand.
Connie MarrasMorton and Gloria Shulman Movement Disorders Clinic and the Edmond J Safra Program in Parkinson's disease, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
Charles H AdlerArizona Parkinson's Disease Consortium, Mayo Clinic Arizona, Scottsdale, Arizona, USA and Banner Sun Health Research Institute, Sun City, Arizona, USA.
Carme JunqueDepartment of Medicine, Faculty of Medicine, IDIBAPS, University of Barcelona, Barcelona, Spain.
Kenn F PedersenThe Norwegian Centre for Movement Disorders, Department of Neurology, and Memory Clinic, Stavanger University Hospital, Stavanger, Norway.
Brit MollenhauerParacelsus-Elena-Klinik, Kassel, Germany, and University Medical Center Goettingen, Department of Neurology, Goettingen, Germany.
Cyrus P ZabetianVA Puget Sound Health Care System and Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA.
Paul J EslingerDepartment of Neurology, Penn State Hershey Medical Center, Hershey, Pennsylvania, USA.
Simon J G LewisBrain & Mind Centre, The University of Sydney, Sydney, Australia.
Ruey-Meei WuDepartment of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
Martin KleinDepartment of Medical Psychology, section Medical Neuropsychology, VU University Medical Center, Amsterdam, The Netherlands.
Maria C Rodriguez-OrozDepartment of Neurology, Hospital Donostia, Donostia, San Sebastian and Ikerbasque, Basque Foundation for Science, Bilbao, Spain.
Davide M CammisuliFifth Local Sanitary Unit, Hospital Psychology, Pisa, Italy and Department of Surgical, Medical, Molecular, and Critical Area Pathology, Pisa University School of Medicine, Pisa, Italy.
Paolo BaroneCenter for Neurodegenerative Diseases (CEMAND) Neuroscience Section, Department of Medicine University of Salerno, Salerno, Italy.
Roberta BiundoSan Camillo Hospital IRCCS, Venice, Italy.
Rob M A de BieDepartment of Neurology, Academic Medical Center Amsterdam, The Netherlands.
Ben A SchmandDepartment of Medical Psychology, Academic Medical Center, Amsterdam, The Netherlands.
Alexander I TrösterDepartment of Clinical Neuropsychology and Center for Neuromodulation, Barrow Neurological Institute, Phoenix, Arizona, USA.
David J BurnInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
Irene LitvanDepartment of Neurosciences University of California San Diego, Parkinson and Other Movement Disorders Center, San Diego, California, USA.
J Vincent FiloteoDepartment of Neurosciences University of California San Diego, Parkinson and Other Movement Disorders Center, San Diego, California, USA.
Gert J GeurtsenDepartment of Medical Psychology, Academic Medical Center, Amsterdam, The Netherlands.
Daniel WeintraubDepartments of Psychiatry and Neurology, University of Pennsylvania School of Medicine, and Parkinson's Disease and Mental Illness Research, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA.
IPMDS Study Group “Validation of Mild Cognitive Impairment in Parkinson Disease”
Academic Medical Center · NLRush University Medical Center · USAmsterdam UMC Location VUmc · NLAmsterdam University of Applied Sciences · NLAzienda Ospedaliera Universitaria Pisana · ITBanner Health · USBarrow Neurological Institute · USBiogipuzkoa Health Research Institute · ESIRCCS San Camillo Hospital · ITNational Taiwan University Hospital · TWNewcastle University · GBNew Zealand Brain Research Institute · NZParacelsus Elena Klinik Kassel · DEPenn State Milton S. Hershey Medical Center · USPhiladelphia VA Medical Center · USStavanger University Hospital · NOUniversitat de Barcelona · ESUniversity of California, San Diego · USUniversity of Salerno · ITUniversity of Sydney · AU

Funding

Project IV: "Alpha-Synuclein Strains & Diverse Synucleinopathies"P50NS053488 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI TROJANOWSKI, JOHN Q. · 2007 to 2017
$20.9M
Udall Center Director's meeting poster awardP50NS062684 · NINDS · UNIVERSITY OF WASHINGTON · PI MONTINE, THOMAS J · 2009 to 2020
$18.3M
NINDS NIH HHS P50 NS053488NINDS NIH HHS P50 NS062684
6 · The paper itself

Abstract

backgroundNumerous neuropsychological tests and test versions are used in Parkinson's disease research, but their relative capacity to detect mild cognitive deficits and their comparability across studies are unknown. The objective of this study was to identify neuropsychological tests that consistently detect cognitive decline in PD across studies.

methodsData from 30 normed neuropsychological tests across 20 international studies in up to 2908 nondemented PD patients were analyzed. A subset of 17 tests was administered to up to 1247 healthy controls. A 2-step meta-analytic approach using standardized scores compared performance in PD with normative data.

resultsPooled estimates of the differences between PD and site-specific healthy controls identified significant cognitive deficits in PD patients on 14 test scores across 5 commonly assessed cognitive domains (attention or working memory, executive, language, memory, and visuospatial abilities), but healthy control performance was statistically above average on 7 of these tests. Analyses based on published norms only, as opposed to direct assessment of healthy controls, showed high between-study variability that could not be accounted for and led to inconclusive results.

conclusionsNormed neuropsychological tests across multiple cognitive domains consistently detect cognitive deficits in PD when compared with site-specific healthy control performance, but relative PD performance was significantly affected by the inclusion and type of healthy controls versus the use of published norms only. Additional research is needed to identify a cognitive battery that can be administered in multisite international studies and that is sensitive to cognitive decline, responsive to therapeutic interventions, and superior to individual cognitive tests. © 2018 International Parkinson and Movement Disorder Society.

Indexed as

Neuropsychological TestsAgedCognitive DysfunctionDatabases, BibliographicFemaleHumansMaleMiddle AgedParkinson DiseasecognitionMCImild cognitive impairmentneuropsychologicalParkinson disease

Identifiers

PMID30216541
PMCPMC6261669
OpenAlexW2891909682

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.