Evidence map›Paper›PMID 30216444›Full record

Observational studyHeadache2018

Long-Term Outcome of Patients With Intractable Chronic Cluster Headache Treated With Injection of Onabotulinum Toxin A Toward the Sphenopalatine Ganglion - An Observational Study.

Irina Aschehoug, Daniel Fossum Bratbak, Erling Andreas Tronvik

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Headache, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Cluster headache: crosspoint between otologists and neurologists-treatment of the sphenopalatine ganglion and systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Pooled it
  2. Hallmarks of primary headache: part 3 - cluster headache.The journal of headache and pain · 2025
    Review
  3. Review
  4. Review
  5. Observational
  6. Cluster headache: state of the art in treatment.Frontiers in pain research (Lausanne, Switzerland) · 2023
    Review
  7. Long-term efficacy of superficial temporal artery ligation and auriculotemporal nerve transection for temporal cluster headache in adolescent.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Irina AschehougDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Daniel Fossum BratbakDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Erling Andreas TronvikDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
St Olav's University Hospital · NONorwegian University of Science and Technology · NO

Funding

Central Norway Regional Health AuthorityNorwegian University of Science and Technology 18873Norwegian University of Science and Technology 2015The Liaison Committee between the Central Norway Regional Health Authority and Norwegian University of Science and Technology 2015/18873
6 · The paper itself

Abstract

objectivesTo investigate long-term outcomes in per-protocol chronic cluster headache patients (n = 7), 18 and 24 months after participation in "Pilot study of sphenopalatine injection of onabotulinumtoxinA for the treatment of intractable chronic cluster headache."

methodsData were collected prospectively through headache diaries, HIT-6, and open questionnaire forms at 18 and 24 months after the first treatment. Patients had access to repeated injections when needed.

resultsAn overall significant reduction in cluster headache attack frequency per month (57.3 ± 35.6 at baseline vs 12.4 ± 15.2 at month 18 and 24.6 ± 19.2 at month 24) was found. In addition, there was a reduction in attacks with severe and unbearably intensity (50.0 ± 38.3 at baseline vs 10.1 ± 14.7 at month 18 and 16.6 ± 13.7 at month 24) and an increase in attack free days (4.2 ± 5.9 at baseline vs 19.1 ± 9.4 at month 18 and 12.9 ± 8.8 at month 24).

conclusionsOur findings suggest sustained headache relief after repeated onabotulinumtoxinA injections toward the sphenopalatine ganglion in intractable chronic cluster headache. A placebo-controlled trial with long-term follow-up is warranted.

Indexed as

Sphenopalatine Ganglion BlockAdultBotulinum Toxins, Type ACluster HeadacheFemaleFollow-Up StudiesHumansMaleMedical RecordsMiddle AgedPatient Generated Health DataPatient Reported Outcome MeasuresPatient SatisfactionPilot ProjectsProspective StudiesRecurrenceBotulinum Toxins, Type Aonabotulinum toxin Abotulinum toxinchronic cluster headachecluster headacheheadachesphenopalatine ganglion

Identifiers

PMID30216444
PMCPMC6282788
OpenAlexW2891490460

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.