ArticleInternational journal of dermatology2019
Incidence of squamous cell carcinoma in oral lichen planus: a 25-year population-based study.
Article in International journal of dermatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Global Prevalence and Incidence Estimates of Oral Lichen Planus: A Systematic Review and Meta-analysis.JAMA dermatology · 2020Pooled it
- Autoimmune Oral Mucosal Diseases in Older Patients: An Overview of Early Recognition and Management in the Primary Care Setting.Geriatrics (Basel, Switzerland) · 2026Review
- Distinct Second Primary Tumor Phenotypes in Oral Squamous Cell Carcinoma According to Exposure Status and Immune Background.Journal of clinical medicine · 2026Article
- Different Approaches to Oral Lichen Planus Treatment: A Narrative Review.International journal of molecular sciences · 2026Review
- The association between skin allergy testing and oral squamous cell carcinoma in oral lichen planus: a retrospective cohort study.Archives of dermatological research · 2025Article
- Asynchronous Teledermatology Reduces Wait Times and Maintains High Adherence to Standard Care for Lichen Planus: A Retrospective Study.Telemedicine reports · 2025Article
- Lichen Planus: What is New in Diagnosis and Treatment?American journal of clinical dermatology · 2024Review
- Mucosal Cancers Arising in Potentially Malignant Lesions of the Oral Mucosa Are Marjolin Ulcers: New Insights Into Old Concepts.Dermatology practical & conceptual · 2024Review
- Role of Oral Microbiota Dysbiosis in the Development and Progression of Oral Lichen Planus.Journal of personalized medicine · 2024Review
- Review
- Bidirectional Association between Lichen Planus and Hepatitis C-An Update Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Review
- [Mucosal lichen planus-a diagnostic and therapeutic challenge].Dermatologie (Heidelberg, Germany) · 2022Review
- Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer.Frontiers in pharmacology · 2022Review
- Bioinformatics analysis reveals thatTranslational cancer research · 2021Article
- Incidence of Lichen Planus and Subsequent Mortality in Finnish Women.Acta dermato-venereologica · 2020Article
- Omega-3 polyunsaturated fatty acids: a promising approach for the management of oral lichen planus.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Review
- The promise of immunotherapy in the treatment of young adults with oral tongue cancer.Laryngoscope investigative otolaryngology · 2020Review
- Oral lichen planus: a novel staging and algorithmic approach and all that is essential to know.F1000Research · 2020Review
- Simulation Modeling of Oral Cancer Development with Risk Stratification: How Potential Screening Programs Can Be Evaluated.MDM policy & practiceArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOral lichen planus (OLP) is a chronic inflammatory condition of the oral mucosa. Multiple studies have shown that approximately 1% of patients with OLP will develop oral squamous cell carcinoma (OSCC), however, no study has taken a population-based multicenter approach to demonstrate this association. Our main objective was to determine the incidence of OSCC in OLP in a specific population and secondarily to assist physicians regarding appropriate long-term monitoring of patients with OLP.
methodsWe conducted a population-based retrospective cohort study. Patients with OLP from 1986 through 2010 were identified using the Rochester Epidemiology Project (REP) for Olmsted County, Minnesota. For each OLP case (n = 303), we randomly selected two age- and gender-matched referents (n = 606). OLP diagnosis was established based on the World Health Organization (WHO) criteria. Medical records were reviewed for development of OSCCafter the OLP diagnosis (index date). The association between OLP and development of OSCC was assessed.
resultsIn total, 303 patients with incident OLP were identified; the overall incidence of OLP per 100,000 person-years was 11.4 (95% CI, 10.1-12.7). Among the OLP cohort, 7 had OSCC (incidence of OSCC, 3.1%; 95% CI, 0.6-6.4%) at 20 years after OLP diagnosis. Three OSCC cases were identified among the referents. Patients with OLP were 4.8 times more likely to have OSCC than the matched referents. The median time to OSCC development was 14.7 years earlier for the OLP cohort.
conclusionsPatients with OLP, particularly the erosive type, have an increased incidence of OSCC development and should be monitored closely.
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Registered trials
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