Evidence map›Paper›PMID 30216431›Full record

ArticleClinical and experimental immunology2018

Identification of circular RNAs hsa_circ_0044235 in peripheral blood as novel biomarkers for rheumatoid arthritis.

Q Luo, L Zhang, X Li, B Fu, Z Deng, C Qing, R Su, J Xu, Y Guo, Z Huang and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.

  1. Pooled it
  2. DecreasedBioMed research international · 2020
    Trial
  3. Article
  4. Review
  5. The significance of m6A-circFOXK2 in CD4Journal of translational autoimmunity · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Circular RNAs: typical biomarkers for bone-related diseases.Journal of Zhejiang University. Science. B · 2022
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Q LuoDepartment of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
L ZhangDepartment of Medical College, Nanchang University, Nanchang, Jiangxi, China.
X LiDepartment of Medical College, Nanchang University, Nanchang, Jiangxi, China.
B FuDepartment of Rheumatology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Z DengDepartment of Medical College, Nanchang University, Nanchang, Jiangxi, China.
C QingDepartment of Intensive Care Unit, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
R SuDepartment of Medical College, Nanchang University, Nanchang, Jiangxi, China.
J XuDepartment of Medical College, Nanchang University, Nanchang, Jiangxi, China.
Y GuoDepartment of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Z HuangDepartment of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
J LiDepartment of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Nanchang University · CNFirst Affiliated Hospital of Nanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) are a new class of RNAs that can be used as biomarkers in clinical blood samples. However, little is known about circRNAs' diagnostic values for rheumatoid arthritis (RA). In this study, the hsa_circ_0054189, hsa_circ_0008675, hsa_circ_0082689, hsa_circ_0082688, hsa_circ_0010932, hsa_circ_0002473 and hsa_circ_0044235 in peripheral blood were determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). For hsa_circ_0044235, only one abnormal expression circRNAs in peripheral blood was selected as a targeted circRNA to explore the diagnostic value for RA. Our work demonstrated that the hsa_circ_0044235 in peripheral blood was decreased significantly in RA patients. The hsa_circ_0044235 in peripheral blood from RA patients did not correlate with C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) or disease activity score 28 (DAS28). Receiver operating characteristic (ROC) curve analysis suggested that the hsa_circ_0044235 in peripheral blood has significant value in the diagnosis of RA. The risk score based on hsa_circ_0044235 in peripheral blood also distinguished significantly the patients with RA from systemic lupus erythematosus (SLE). This study suggests that the hsa_circ_0044235 in peripheral blood may be a potential biomarker of patients with RA.

Indexed as

Arthritis, RheumatoidAutoantibodiesBiomarkersBlood SedimentationC-Reactive ProteinFemaleHumansLupus Erythematosus, SystemicMaleReverse Transcriptase Polymerase Chain ReactionRheumatoid FactorRNARNA, CircularAutoantibodiesBiomarkersC-Reactive ProteinRheumatoid FactorRNARNA, Circularbiomarkercircular RNAsrheumatoid arthritis

Identifiers

PMID30216431
PMCPMC6156811
OpenAlexW2890661256

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.