ArticlePloS one2018
Severity and properties of cardiac damage caused by Streptococcus pneumoniae are strain dependent.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 36 citations in OpenAlex.
- Role of bacterial pathogens and toxins in sepsis-related myocardial injury: a scoping review.BMJ open · 2026Article
- A new murine gram-negative sepsis model with standard care satisfies Sepsis-3 and reproduces clinical pathology.Intensive care medicine experimental · 2026Article
- Allele-specific zinc metalloprotease B influences cardiac damage during invasive pneumococcal disease.Cell reports · 2025Article
- Structure, Function, and Regulation of LytA: TheMicroorganisms · 2025Review
- Novel coenzyme Q6 genetic variant increases susceptibility to pneumococcal disease.Nature immunology · 2024Article
- The prostaglandin D2 antagonist asapiprant ameliorates clinical severity in young hosts infected with invasiveInfection and immunity · 2024Article
- Diabetes Mellitus and Pneumococcal Pneumonia.Diagnostics (Basel, Switzerland) · 2024Review
- Heart-lung crosstalk in acute respiratory distress syndrome.Frontiers in physiology · 2024Review
- Regulated cell death pathways in cardiomyopathy.Acta pharmacologica Sinica · 2023Review
- The Global Burden of Community-Acquired Pneumonia in Adults, Encompassing Invasive Pneumococcal Disease and the Prevalence of Its Associated Cardiovascular Events, with a Focus on Pneumolysin and Macrolide Antibiotics in Pathogenesis and Therapy.International journal of molecular sciences · 2023Review
- Risk of Acute Myocardial Infarction Among Patients With Laboratory-Confirmed Invasive Pneumococcal Disease: A Self-Controlled Case Series Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Acute Respiratory Distress Syndrome in Patients with Cardiovascular Disease.Methodist DeBakey cardiovascular journal · 2023Review
- Lectin-like oxidized low-density lipoprotein receptor 1 attenuates pneumonia-induced lung injury.JCI insight · 2022Article
- Article
- Extending applications of AFM to fluidic AFM in single living cell studies.Journal of cellular physiology · 2022Review
- Acetylsalicylic acid use is associated with improved survival in bacteremic pneumococcal pneumonia: A long-term nationwide study.Journal of internal medicine · 2022Article
- Serotype-specific Cardiac Involvement in Pneumococcal Pneumonia.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Major Adverse Cardiovascular Events During Invasive Pneumococcal Disease Are Serotype Dependent.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Observational
- Cardiovascular complications ofBMJ case reports · 2021Review
- Pneumococcal serotypes causing non-invasive pneumonia in adults from a South Indian tertiary care hospital and the impact of the newer conjugate vaccines.Access microbiology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Streptococcus pneumoniae is an opportunistic Gram-positive pathogen that can cause invasive disease. Recent studies have shown that S. pneumoniae is able to invade the myocardium and kill cardiomyocytes, with one-in-five adults hospitalized for pneumococcal pneumonia having a pneumonia-associated adverse cardiac event. Furthermore, clinical reports have shown up to a 10-year increased risk of adverse cardiac events in patients formerly hospitalized for pneumococcal bacteremia. In this study, we investigated the ability of nine S. pneumoniae clinical isolates, representing eight unique serotypes, to cause cardiac damage in a mouse model of invasive disease. Following intraperitoneal challenge of C57BL/6 mice, four of these strains (D39, WU2, TIGR4, and 6A-10) caused high-grade bacteremia, while CDC7F:2617-97 and AMQ16 caused mid- and low-grade bacteremia, respectively. Three strains did not cause any discernible disease. Of note, only the strains capable of high-grade bacteremia caused cardiac damage, as inferred by serum levels of cardiac troponin-I. This link between bacteremia and heart damage was further corroborated by Hematoxylin & Eosin and Trichrome staining which showed cardiac cytotoxicity only in D39, WU2, TIGR4, and 6A-10 infected mice. Finally, hearts infected with these strains showed varying histopathological characteristics, such as differential lesion formation and myocytolysis, suggesting that the mechanism of heart damage varied between strains.
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