SEP-1: The Lactate Myth and Other Fairytales.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

6 citing papers in PubMed.

1. A systematic review and meta-analysis of noradrenaline compared to adrenaline in the management of septic shock.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2025
   Review
2. Compliance with SEP-1 guidelines is associated with improved outcomes for septic shock but not for severe sepsis.Journal of intensive medicine · 2022
   Article
3. RegardingJournal of thoracic disease · 2021
   Article
4. Failure to Clear Intermediate Lactate Levels in Ward Patients With Admission Blood Cultures Did Not Increase the Risk of Intensive Care Unit Transfer or In-Hospital Mortality: A Retrospective Cohort Study.Cureus · 2021
   Article
5. Driving blind: instituting SEP-1 without high quality outcomes data.Journal of thoracic disease · 2020
   Review
6. Lactate guided resuscitation-nothing is more dangerous than conscientious foolishness.Journal of thoracic disease · 2019
   Article

Corrections and comments

• Comment on
  Compliance With the National SEP-1 Quality Measure and Association With Sepsis Outcomes: A Multicenter Retrospective Cohort Study.2018

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as