Evidence map›Paper›PMID 30216070›Full record

ArticleThe Journal of organic chemistry2018

A Copper-Mediated Conjugate Addition Approach to Analogues of Aconitine-Type Diterpenoid Alkaloids.

Nicolle A Doering, Kevin G M Kou, Krissada Norseeda, Jack C Lee, Christopher J Marth, Gary M Gallego, Richmond Sarpong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicolle A DoeringDepartment of Chemistry , University of California , Berkeley , California 94720 , United States.
Kevin G M KouDepartment of Chemistry , University of California , Berkeley , California 94720 , United States.
Krissada NorseedaDepartment of Chemistry , University of California , Berkeley , California 94720 , United States.
Jack C LeeDepartment of Chemistry , University of California , Berkeley , California 94720 , United States.
Christopher J MarthDepartment of Chemistry , University of California , Berkeley , California 94720 , United States.
Gary M GallegoDepartment of Chemistry , University of California , Berkeley , California 94720 , United States.
Richmond SarpongDepartment of Chemistry , University of California , Berkeley , California 94720 , United States.ORCID 0000-0002-0028-6323

Funding

Total Synthesis of Bioactive Natural ProductsR01GM086374 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI SARPONG, RICHMOND · 2009 to 2018
$2.7M
A proposal for the purchase of a new Cu anode Microsource X-ray Diffractometer wiS10RR027172 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI RAYMOND, KENNETH N · 2010 to 2010
$500k
Rhodium-Catalyzed 1,2-Addition of Pinacolboronic Esters into KetonesF31GM095238 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI GALLEGO, GARY MICHAEL · 2012 to 2013
$64k
NCRR NIH HHS S10 RR027172NIGMS NIH HHS F31 GM095238NIGMS NIH HHS R01 GM086374
6 · The paper itself

Abstract

A copper-mediated conjugate addition of electron-rich aryl groups into a complex vinyl nitrile using arylmagnesium bromides is reported. The conjugate addition adducts were advanced toward the synthesis of designed aconitine-type analogues. The variation in oxygenation patterns on the arene coupling partner, introduced through the current conjugate addition approach, may ultimately provide insight into structure-activity relationships of the diterpenoid alkaloids.

Indexed as

AconitineCopperElectronsMolecular StructureNitrilesSolventsStructure-Activity RelationshipAconitineCopperNitrilesSolvents

Identifiers

PMID30216070
PMCPMC6214151

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.