Evidence map›Paper›PMID 30215859›Full record

ReviewComprehensive Physiology2018

Colonic Potassium Absorption and Secretion in Health and Disease.

Vazhaikkurichi M Rajendran, Geoffrey I Sandle

Open access · greenAbstract readReview
In one paragraph

Review in Comprehensive Physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Ion transport and epithelial barrier dysfunction in experimental models of ulcerative colitis.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Review
  8. Review
  9. Dietary NaCellular and molecular life sciences : CMLS · 2023
    Article
  10. Is intestinal transport dysfunctional in COVID-19-related diarrhea?American journal of physiology. Gastrointestinal and liver physiology · 2023
    Article
  11. Article
  12. Review
  13. Hyperkalemia in patients undergoing hemodialysis: Its pathophysiology and management.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2022
    Review
  14. Article
  15. Aldosterone up-regulates basolateral NaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  16. Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  17. Increased colonic KScientific reports · 2021
    Article
  18. Penicillin G Induces H+, K+-ATPase via a Nitric Oxide-Dependent Mechanism in the Rat Colonic Crypt.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2020
    Article
  19. Parallel intermediate conductance KAmerican journal of physiology. Gastrointestinal and liver physiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Vazhaikkurichi M RajendranDepartment of Biochemistry, West Virginia University School of Medicine, Morgantown, West Virginia, USA.
Geoffrey I SandleLeeds Institute of Biomedical and Clinical Sciences, St James's University Hospital, Leeds, United Kingdom.
St James's University Hospital · GBWest Virginia University · US

Funding

Role of IK channels in rat distal colonR01DK018777 · NIDDK · YALE UNIVERSITY · PI RAJENDRAN, VAZHAIKKURICHI M. · 1986 to 2010
$2.5M
Role of BK Channels in K+-driven Colonic Water Secretion in Health and DiseaseR01DK104791 · NIDDK · WEST VIRGINIA UNIVERSITY · PI RAJENDRAN, VAZHAIKKURICHI M. · 2015 to 2019
$1.7M
Aldosterone Activation of Trans-epithelial Iron Absorption in Human ColonR21DK112085 · NIDDK · WEST VIRGINIA UNIVERSITY · PI RAJENDRAN, VAZHAIKKURICHI M. · 2018 to 2019
$404k
Medical Research CouncilNIDDK NIH HHS R01 DK018777NIDDK NIH HHS R01 DK104791NIDDK NIH HHS R21 DK112085Wellcome Trust
6 · The paper itself

Abstract

The colon has large capacities for K

Indexed as

Intestinal AbsorptionAnimalsColonHumansPotassiumPotassium ChannelsPotassiumPotassium Channels

Identifiers

PMID30215859
PMCPMC9769410
OpenAlexW2899855977

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.