Evidence map›Paper›PMID 30215325›Full record

ArticleStem cells and development2018

Accelerate Healing of Severe Burn Wounds by Mouse Bone Marrow Mesenchymal Stem Cell-Seeded Biodegradable Hydrogel Scaffold Synthesized from Arginine-Based Poly(ester amide) and Chitosan.

Bhagwat V Alapure, Yan Lu, Mingyu He, Chih-Chang Chu, Hongying Peng, Filipe Muhale, Yue-Liang Brewerton, Bruce Bunnell, Song Hong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells and development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Bhagwat V Alapure1 Neuroscience Center of Excellence, Louisiana State University Health Sciences Center , New Orleans, Louisiana.
Yan Lu1 Neuroscience Center of Excellence, Louisiana State University Health Sciences Center , New Orleans, Louisiana.
Mingyu He2 Department of Fiber Science and Apparel Design, Cornell University , Ithaca, New York.
Chih-Chang Chu2 Department of Fiber Science and Apparel Design, Cornell University , Ithaca, New York.
Hongying Peng4 Department of Environmental Health, University of Cincinnati College of Medicine , Cincinnati, Ohio.
Filipe Muhale1 Neuroscience Center of Excellence, Louisiana State University Health Sciences Center , New Orleans, Louisiana.
Yue-Liang Brewerton5 Department of Nutrition, University of California , Davis, California.
Bruce Bunnell6 Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine , New Orleans, Louisiana.
Song Hong1 Neuroscience Center of Excellence, Louisiana State University Health Sciences Center , New Orleans, Louisiana.
Louisiana State University Health Sciences Center New Orleans · USCornell University · USTulane University · USUniversity of California, Davis · USUniversity of Cincinnati Medical Center · US

Funding

PROHEALING LIPID AUTOCRINES PARACRINES OF MACROPHAGES AND NERVES IN DIABETIC WOUND RE-INNERVATION - NANOPARTICLE-SUSTAINED RELEASER01DK087800 · NIDDK · LSU HEALTH SCIENCES CENTER · PI HONG, SONG · 2010 to 2018
$2.3M
NIDDK NIH HHS R01 DK087800
6 · The paper itself

Abstract

Severe burns are some of the most challenging problems in clinics and still lack ideal modalities. Mesenchymal stem cells (MSCs) incorporated with biomaterial coverage of burn wounds may offer a viable solution. In this report, we seeded MSCs to a biodegradable hybrid hydrogel, namely ACgel, that was synthesized from unsaturated arginine-based poly(ester amide) (UArg-PEA) and chitosan derivative. MSC adhered to ACgels. ACgels maintained a high viability of MSCs in culture for 6 days. MSC seeded to ACgels presented well in third-degree burn wounds of mice at 8 days postburn (dpb) after the necrotic full-thickness skin of burn wounds was debrided and filled and covered by MSC-carrying ACgels. MSC-seeded ACgels promoted the closure, reepithelialization, granulation tissue formation, and vascularization of the burn wounds. ACgels alone can also promote vascularization but less effectively compared with MSC-seeded ACgels. The actions of MSC-seeded ACgels or ACgels alone involve the induction of reparative, anti-inflammatory interleukin-10, and M2-like macrophages, as well as the reduction of inflammatory cytokine TNFα and M1-like macrophages at the late inflammatory phase of burn wound healing, which provided the mechanistic insights associated with inflammation and macrophages in burn wounds. For the studied regimens of these treatments, no toxicity was identified to MSCs or mice. Our results indicate that MSC-seeded ACgels have potential use as a novel adjuvant therapy for severe burns to complement commonly used skin grafting and, thus, minimize the downsides of grafting.

Indexed as

Mesenchymal Stem Cell TransplantationAmidesAnimalsArginineBiodegradable PlasticsBurnsChitosanHumansHydrogel, Polyethylene Glycol DimethacrylateMesenchymal Stem CellsMicePolyestersTissue ScaffoldsWound HealingAmidesArginineBiodegradable PlasticsChitosanHydrogel, Polyethylene Glycol DimethacrylatePolyesterschronic inflammationhydrogels synthesized from unsaturated arginine-based Poly(ester amide) and chitosanM1- or M2-like macrophagesmesenchymal stem cellsMSC-seeded ACgelssevere burn

Identifiers

PMID30215325
PMCPMC6276600
OpenAlexW2889566561

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.