Evidence map›Paper›PMID 30215216›Full record

ArticlePsychopharmacology2019

Increased amygdalar metabotropic glutamate receptor 7 mRNA in a genetic mouse model of impaired fear extinction.

Richard M O'Connor, Cian P McCafferty, Javier A Bravo, Nicolas Singewald, Andrew Holmes, John F Cryan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 4 countries.

Richard M O'ConnorDepartment of Anatomy and Neuroscience and APC Microbiome Institute, University College Cork, Cork, Ireland. richard.oconnor@mssm.edu.
Cian P McCaffertyDepartment of Anatomy and Neuroscience and APC Microbiome Institute, University College Cork, Cork, Ireland.
Javier A BravoGrupo de NeuroGastroBioquímica, Laboratorio e Química Biológica & Bioquímica de Sistemas, Instituto de Química, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
Nicolas SingewaldDepartment of Pharmacology and Toxicology, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria.
Andrew HolmesLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA.
John F CryanDepartment of Anatomy and Neuroscience and APC Microbiome Institute, University College Cork, Cork, Ireland.
APC Microbiome Institute · IEMount Sinai Hospital · USNational Institute on Alcohol Abuse and Alcoholism · USPontificia Universidad Católica de Valparaíso · CLUniversität Innsbruck · ATYale University · US

Funding

Mouse models of stress disorders and addictionZIAAA000411 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI HOLMES, ANDREW · 2009 to 2025
$37.7M
Mouse models of the early life origins of stress disordeZ01AA000411 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI HOLMES, ANDREW · 2004 to 2008
$1.9M
Intramural NIH HHS Z01 AA000411
6 · The paper itself

Abstract

rationalePost-traumatic stress disorder (PTSD) is a devastating anxiety-related disorder which develops subsequent to a severe psychologically traumatic event. Only ~ 9% of people who experience such a trauma develop PTSD. It is clear that a number of factors, including genetics, influence whether an individual will develop PTSD subsequent to a trauma. The 129S1/SvImJ (S1) inbred mouse strain displays poor fear extinction and may be useful to model this specific aspect of PTSD. The metabotropic glutamate receptor 7 (mGlu

resultsCompared to the B6 strain, S1 mice had increased mGlu

conclusionsThese data show altered mGlu

Indexed as

Disease Models, AnimalAmygdalaAnimalsAnxiety DisordersExtinction, PsychologicalFearHippocampusMaleMiceMice, Inbred C57BLMice, TransgenicPrefrontal CortexReceptors, Metabotropic GlutamateRNA, Messengermetabotropic glutamate receptor 7Receptors, Metabotropic GlutamateRNA, MessengermGlu7 receptor expressionPost-traumatic stress disorderTrauma

Identifiers

PMID30215216
PMCPMC6739849
OpenAlexW2890897912

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.