ArticleEnvironmental science and pollution research international2018
Determination of azole fungal residues in soils and detection of Aspergillus fumigatus-resistant strains in market gardens of Eastern France.
Article in Environmental science and pollution research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Comprehensive Review of Environmental Surveillance for Azole-ResistantJournal of fungi (Basel, Switzerland) · 2025Review
- High prevalence of azole resistance among environmentalFrontiers in microbiology · 2025Article
- Demethylation Inhibitor Fungicides Have a Significantly Detrimental Impact on Population Growth and Composition of Nectar Microbial Communities.Microbial ecology · 2024Article
- Occurrence of Aspergillus fumigatus azole resistance in soils from Switzerland.Medical mycology · 2023Article
- Field-Crop Soils in Eastern France: Coldspots of Azole-ResistantJournal of fungi (Basel, Switzerland) · 2023Article
- Article
- Collateral consequences of agricultural fungicides on pathogenic yeasts: A One Health perspective to tackle azole resistance.Mycoses · 2022Review
- Selection and Amplification of Fungicide Resistance inMicroorganisms · 2021Review
- Review
- Molecular Epidemiology of Azole-ResistantFrontiers in cellular and infection microbiology · 2021Article
- Molecular Epidemiology of Azole-ResistantJournal of fungi (Basel, Switzerland) · 2020Article
- Article
- Detecting Azole-Antifungal Resistance inJournal of fungi (Basel, Switzerland) · 2020Review
- Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medical azole antifungals are major compounds used to prevent and to treat invasive aspergillosis (IA). Azole fungicides, called DMI (14-alpha demethylase inhibitors), are also widely used for crop protection and have been reported to be linked to azole-resistant A. fumigatus (aR-Af) development in the environment. The aim of this study was to determine whether or not market gardens that spray DMIs in Eastern France are also affected by the presence of aR-Af. Forty aR-Afs were detected in soils in only two of the four market gardens using DMIs, with 23% (7/30) and 10% (3/30) of soils containing aR-Af. A total of 87.5% of these isolates had the TR34/L98H mutation and 22.5% the TR46/Y121F/T289A mutation on the cyp51A gene. Analyses of residual azole concentrations in soils showed the presence of difenoconazole for up to 2 years after spraying, but only in soils of market gardens where aR-Af was detected. It is very important to identify professional activities that could lead to aR-Af development and to develop preventive measures for at-risk patients living near professional activities using DMIs. We have to better understand why, in some cases, the use of DMI is not linked to aR-Af. Measures should be taken to avoid the use of DMI conferring cross-resistance to preserve the efficiency of human therapeutics.
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