Evidence map›Paper›PMID 30215202›Full record

Trial reportJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2019

Circulating Leptin and Branched Chain Amino Acids-Correlation with Intraductal Papillary Mucinous Neoplasm Dysplastic Grade.

Michele T Yip-Schneider, Rachel Simpson, Rosalie A Carr, Huangbing Wu, Hao Fan, Ziyue Liu, Murray Korc, Jianjun Zhang, C Max Schmidt

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Clinical and Molecular Attributes and Evaluation of Pancreatic Cystic Neoplasm.Biochimica et biophysica acta. Reviews on cancer · 2023
    Review
  8. Recent Metabolomics Analysis in Tumor Metabolism Reprogramming.Frontiers in molecular biosciences · 2021
    Review
  9. Genetic and Circulating Biomarker Data Improve Risk Prediction for Pancreatic Cancer in the General Population.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Michele T Yip-SchneiderDepartment of Surgery, Indiana University School of Medicine, 545 Barnhill Drive EH 129, Indianapolis, IN, 46202, USA.
Rachel SimpsonDepartment of Surgery, Indiana University School of Medicine, 545 Barnhill Drive EH 129, Indianapolis, IN, 46202, USA.
Rosalie A CarrDepartment of Surgery, Indiana University School of Medicine, 545 Barnhill Drive EH 129, Indianapolis, IN, 46202, USA.
Huangbing WuDepartment of Surgery, Indiana University School of Medicine, 545 Barnhill Drive EH 129, Indianapolis, IN, 46202, USA.
Hao FanDepartment of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, 1050 Wishard Blvd. RG5118, Indianapolis, IN, 46202, USA.
Ziyue LiuDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
Murray KorcIndiana University Simon Cancer Center, Indianapolis, IN, USA.
Jianjun ZhangIndiana University Simon Cancer Center, Indianapolis, IN, USA. JZ21@iu.edu.
C Max SchmidtDepartment of Surgery, Indiana University School of Medicine, 545 Barnhill Drive EH 129, Indianapolis, IN, 46202, USA. maxschmi@iupui.edu.
Indiana University – Purdue University Indianapolis · USIndiana University Health · USIndiana University School of Medicine

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT: NEUROLOGICAL DISORDERS:ALZ, PDC06RR020128 · NCRR · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI FIFE, ROSE S · 2004 to 2004
$3.7M
Identifying insulin resistance biomarkers and metabolomic signature as predictors of precursors to pancreatic cancerR21CA209366 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI SCHMIDT, CHRISTIAN MAXIMILLIAN, ZHANG, JIANJUN · 2016 to 2017
$375k
NCATS NIH HHS UL1 TR001108NCATS NIH HHS UL1 TR002529NCI NIH HHS R21 CA209366NCRR NIH HHS C06 RR020128
6 · The paper itself

Abstract

backgroundThe most common type of mucinous pancreatic cyst that may progress to pancreatic cancer is intraductal papillary mucinous neoplasm (IPMN). Low-risk IPMN with low-/moderate-grade dysplasia may be safely watched, whereas high-risk IPMN with high-grade dysplasia or invasive components should undergo resection. However, there is currently no reliable means of making this distinction. We hypothesize that blood concentrations of insulin resistance biomarkers may aid in the differentiation of low- and high-risk IPMN.

methodsPlasma/serum was collected from consented patients undergoing pancreatic resection. IPMN diagnosis and dysplastic grade were confirmed by surgical pathology. The study included 235 IPMN (166 low/moderate grade, 39 high grade, 30 invasive). Circulating levels of leptin, branched chain amino acids (BCAA), and retinol-binding protein-4 (RBP-4) were measured by enzyme-linked immunoassay and correlated with surgical pathology.

resultsCirculating leptin levels (mean ± SE) were significantly higher in patients with low/moderate IPMN than in high-grade/invasive IPMN (15,803 ± 1686 vs. 10,275 ± 1228 pg/ml; p = 0.0086). Leptin levels were positively correlated with BMI (r = 0.65, p < 0.0001) and were higher in females (p < 0.0001). Stratified analysis showed that mean leptin levels were significantly different between low/moderate and high/invasive IPMNs only in females (24,383 ± 2748 vs. 16,295 ± 2040 pg/ml; p = 0.020). Conversely, circulating BCAA levels were lower in low/moderate IPMN than in high-grade/invasive IPMN (0.38 ± 0.007 vs. 0.42 ± 0.01 mM; p = 0.011). No significant differences in RBP-4 levels were observed.

conclusionsCirculating leptin in females and BCAA correlates with IPMN dysplastic grade and, if combined with clinical characteristics, have the potential to improve clinical decision-making.

Indexed as

AdultAgedAmino Acids, Branched-ChainBiomarkers, TumorCase-Control StudiesCross-Sectional StudiesDiagnosis, DifferentialFemaleHumansLeptinMaleMiddle AgedNeoplasm GradingPancreatic CystPancreatic Intraductal NeoplasmsPrecancerous ConditionsAmino Acids, Branched-ChainBiomarkers, TumorLeptinRBP4 protein, humanRetinol-Binding Proteins, PlasmaBCAABiomarkerIPMNLeptinPancreatic cyst

Identifiers

PMID30215202
PMCPMC6416083
OpenAlexW2891802576

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.