ArticleSleep & breathing = Schlaf & Atmung2019
Atypical sleep in critically ill patients on mechanical ventilation is associated with increased mortality.
Article in Sleep & breathing = Schlaf & Atmung, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Light and Sound Modification on Sleep Quality and Circadian Rhythm in the Medical Intensive Care Unit Patients
Sleep Disturbances in Hospitalized Patients as a Risk Factor for Delirium
Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- EEG spindles integrity in critical care adults. Analysis of a randomized trial.Acta neurologica Scandinavica · 2021Trial
- Trial
- Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus.Annals of clinical and translational neurology · 2026Article
- Clinical Care Interaction and Patient Sleep in the Intensive Care Unit: A Secondary Data Analysis.Nursing in critical care · 2026Article
- Glymphatic dysfunction: a unifying hypothesis for delirium.Nature reviews. Neurology · 2026Review
- A pilot, parallel-group, blinded, placebo-controlled, randomiseCritical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Improving sleep in ICUs through real-time sleep monitoring: a proof-of-concept study.Annals of intensive care · 2026Article
- Article
- Effect of sleep quality on weaning from mechanical ventilation: A scoping review.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025Review
- Impact of sleep disturbances on outcomes in intensive care units.Critical care (London, England) · 2024Observational
- Sleep Assessment in Critically Ill Patients With Acute Hypoxemic Respiratory Failure.Respiratory care · 2023Observational
- Enhancing circadian rhythms-the circadian MEGA bundle as novel approach to treat critical illness.Annals of translational medicine · 2023Review
- Nocturnal increase in cerebrospinal fluid secretion as a circadian regulator of intracranial pressure.Fluids and barriers of the CNS · 2023Article
- Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2023Article
- Sleep and critical illness: a review.Frontiers in medicine · 2023Review
- Sleep cycle in children with severe acute bronchopneumonia during mechanical ventilation at different depths of sedation.BMC pediatrics · 2022Article
- Sleep, circadian rhythms and outcomes in intensive care unit.Frontiers in neurologyReview
- Sleep quality assessment in intensive care: actigraphy vs. Richards-Campbell sleep questionnaire.Sleep science (Sao Paulo, Brazil)Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep patterns in critically ill patients' polysomnographic sleep studies (PSG) are severely abnormal. PURPOSE: We aimed to investigate the association of atypical sleep patterns, micro-sleep phenomena (sleep spindles and K-complexes) and rapid eye movement (REM) sleep with intensive care unit (ICU), in-hospital and 90-day mortality in conscious critically ill patients on mechanical ventilation.
methodThis was a prospective descriptive study. We analysed 52 PSGs recorded in conscious critically ill patients on mechanical ventilation. PSGs were scored according to standard classification when possible. Otherwise, modified classification proposed for scoring sleep in critically ill patients was used. The association of PSG findings with mortality was studied using logistic regression and Weibull model of survival analysis.
resultsThe presence of atypical sleep patterns in accordance with modified sleep scoring classification was associated with higher odds for ICU mortality (odds ratio 11.63; p = 0.03). The absence of K-complexes was associated with higher odds for ICU mortality (odds ratio 11.63; p = 0.03), while the absence of sleep spindles was associated with higher odds for in-hospital (odds ratio 7.80; p = 0.02) and 90-day mortality (odds ratio 5.51; p = 0.02). Loss of sleep spindles was associated with higher mortality risk with cutoff point 90 days (hazard ratio 3.87; p = 0.03).
conclusionsThe presence of atypical sleep and absence of normal PSG sleep characteristics in conscious critically ill patients on mechanical ventilation indicates involvement of sleep producing brain structures in the pathological process and is associated with poor outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.