ArticleSkeletal radiology2019
Preliminary investigation of brown adipose tissue assessed by PET/CT and cancer activity.
Article in Skeletal radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Determinants of activity of brown adipose tissue in lymphoma patients.Scientific reports · 2020Trial
- Brown Adipose Tissue in Breast Cancer Evaluated by [Molecular imaging and biology · 2020Trial
- Association between brown adipose tissue activity and clinical outcomes in melanoma: a retrospective PET/CT analysis.Immuno-oncology technology · 2026Article
- Brown Adipocyte Promotes HR+ Breast Cancer Invasiveness Through IRX3-Mediated Mitochondrial Dysfunction.Metabolites · 2026Article
- Exploring Adipose Tissue Complexity Through Omics Approaches: Implications for Health and Disease.Cells · 2026Review
- Mitochondrial uncoupling, energy substrate utilization, and brown adipose tissue as therapeutic targets in cancer.npj metabolic health and disease · 2025Review
- Physical Activity, Exerkines, and Their Role in Cancer Cachexia.International journal of molecular sciences · 2025Review
- Brown adipose tissue activity on PET/CT and the course of Hodgkin lymphoma.Journal of cancer research and clinical oncology · 2025Article
- Brown adipose tissue is associated with reduced weight loss and risk of cancer cachexia: A retrospective cohort study.Clinical nutrition (Edinburgh, Scotland) · 2025Article
- Prediction of TP53 mutations across female reproductive system pan-cancers using deep multimodal PET/CT radiogenomics.Frontiers in medicine · 2025Article
- Hyperactive browning and hypermetabolism: potentially dangerous element in critical illness.Frontiers in endocrinology · 2024Review
- Emerging technologies in adipose tissue research.Adipocyte · 2023Review
- Off the Beaten Path in Oncology: Active Brown Adipose Tissue by Virtue of Molecular Imaging.Current issues in molecular biology · 2023Article
- Treatment Resulting Changes in Volumes of High-International journal of molecular sciences · 2023Article
- Brown adipocytes promote epithelial mesenchymal transition of neuroblastoma cells by inducing PPAR-γ/UCP2 expression.Adipocyte · 2022Article
- The evolving view of thermogenic fat and its implications in cancer and metabolic diseases.Signal transduction and targeted therapy · 2022Review
- Comparison of BMIPP-SPECT/CT toInternational journal of molecular sciences · 2022Article
- Imaging modalities for diagnosis and monitoring of cancer cachexia.EJNMMI research · 2021Review
- Comparative [Adipocyte · 2020Article
- Pheochromocytoma and Paraganglioma Patients With Poor Survival Often Show Brown Adipose Tissue Activation.The Journal of clinical endocrinology and metabolism · 2020Article
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Abstract
objectiveTo determine the role of brown adipose tissue (BAT) in cancer activity. MATERIALS AND
methodsThe study group comprised 142 patients (121 female, 21 male; mean age, 49 ± 16 years) who underwent F18-FDG PET/CT (PET/CT) for staging or surveillance of cancer and who were BAT-positive on PET/CT. BAT volume by PET/CT, abdominal (visceral and subcutaneous) fat and paraspinous muscle cross-sectional areas (CSA) were assessed. Groups with and without active cancer on PET/CT were compared using a two-sided paired t test. Linear regression analyses between BAT and body composition parameters were performed.
resultsThere were 62 patients (54 female, eight male) who had active cancer on PET/CT and 80 patients (67 female, 13 male) without active cancer. Groups were similar in age and BMI (p ≥ 0.4), abdominal fat and muscle CSA, fasting glucose, and outside temperature at time of scan (p ≥ 0.2). Patients who had active cancer on PET/CT had higher BAT volume compared to patients without active cancer (p = 0.009). In patients without active cancer, BAT was positively associated with BMI and abdominal fat depots (r = 0.46 to r = 0.59, p < 0.0001) while there were no such associations in patients with active cancer (p ≥ 0.1). No associations between BAT and age or muscle CSA were found (p ≥ 0.1).
conclusionsBAT activity is greater in patients with active cancer compared to age-, sex-, and BMI-matched BAT-positive patients without active cancer, suggesting a possible role of BAT in cancer activity.
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