Evidence map›Paper›PMID 30215097›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2018

A new immunodeficient retinal dystrophic rat model for transplantation studies using human-derived cells.

Biju B Thomas, Danhong Zhu, Tai-Chi Lin, Young Chang Kim, Magdalene J Seiler, Juan Carlos Martinez-Camarillo, Bin Lin, Yousuf Shad, David R Hinton, Mark S Humayun

Abstract read
PubMed Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Animal models for the evaluation of retinal stem cell therapies.Progress in retinal and eye research · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. A New Optokinetic Testing Method to Measure Rat Vision.Journal of visualized experiments : JoVE · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. The Prospects for Retinal Organoids in Treatment of Retinal Diseases.Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Biju B ThomasDepartment of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, 90033, USA. biju.thomas@med.usc.edu.
Danhong ZhuDepartment of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, 90033, USA.
Tai-Chi LinDepartment of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, 90033, USA.
Young Chang KimDepartment of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, 90033, USA.
Magdalene J SeilerDepartment of Physical Medicine & Rehabilitation, University of California-Irvine, Irvine, CA, USA.
Juan Carlos Martinez-CamarilloDepartment of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, 90033, USA.
Bin LinDepartment of Physical Medicine & Rehabilitation, University of California-Irvine, Irvine, CA, USA.
Yousuf ShadDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada.
David R HintonDepartment of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, 90033, USA.
Mark S HumayunDepartment of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, 90033, USA.

Funding

California Institute for Regenerative Medicine DT3California Institute for Regenerative Medicine TR4-06648
6 · The paper itself

Abstract

purposeTo create new immunodeficient Royal College of Surgeons (RCS) rats by introducing the defective MerTK gene into athymic nude rats.

methodsFemale homozygous RCS (RCS-p+/RCS-p+) and male nude rats (Hsd:RH-Foxn1

resultsApproximately 6% of the F2 pups (11/172) were homozygous for RCS-p+ gene and Foxn1

conclusionsThis new rat animal model developed by crossing RCS rats and athymic nude rats is suitable for conducting retinal transplantation experiments involving xenografts.

Indexed as

Disease Models, AnimalAnimalsCell Survivalc-Mer Tyrosine KinaseElectroretinographyFemaleGenotyping TechniquesGraft SurvivalHuman Embryonic Stem CellsHumansImmunologic Deficiency SyndromesInduced Pluripotent Stem CellsMalePhenotypeRatsRats, Nudec-Mer Tyrosine KinaseHuman-derived cellsImmunodeficiencyRetinal dystrophyRetinal transplantation

Identifiers

PMID30215097

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.