ArticleNetwork neuroscience (Cambridge, Mass.)2018
Functional and structural connectome properties in the 5XFAD transgenic mouse model of Alzheimer's disease.
Article in Network neuroscience (Cambridge, Mass.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of the relationship between magnetic resonance imaging based resting-state and structural networks in the rodent brain.Frontiers in neuroscience · 2023Pooled it
- Dissociable, species-specific impact of Aβ on static and dynamic functional connectomes.bioRxiv : the preprint server for biology · 2026Article
- Fibre supplementation alters the gastrointestinal microbiome, the microbial metabolites and indicators of neurodegeneration in a mouse model of Alzheimer´s disease.Scientific reports · 2025Article
- Astrocytes, via RTP801, contribute to cognitive decline by disrupting GABAergic-regulated connectivity and driving neuroinflammation in an Alzheimer's disease mouse model.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Modeling functional connectivity with learning and memory in a mouse model of Alzheimer's disease.Frontiers in neuroimaging · 2025Article
- Brain network fingerprints of Alzheimer's disease risk factors in mouse models with humanized APOE alleles.Magnetic resonance imaging · 2024Article
- Identifying the bioimaging features of Alzheimer's disease based on pupillary light response-driven brain-wide fMRI in awake mice.Nature communications · 2024Article
- Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction.Molecular psychiatry · 2024Article
- APOE, Immune Factors, Sex, and Diet Interact to Shape Brain Networks in Mouse Models of Aging.bioRxiv : the preprint server for biology · 2024Article
- Functional Deficits of 5×FAD Neural Stem Cells Are Ameliorated by Glutathione Peroxidase 4.Cells · 2022Article
- Article
- Changes in Brain Functional and Effective Connectivity After Treatment for Breast Cancer and Implications for Intervention Targets.Brain connectivity · 2022Article
- Connectomic analysis of Alzheimer's disease using percolation theory.Network neuroscience (Cambridge, Mass.) · 2022Article
- Neuroimaging of Mouse Models of Alzheimer's Disease.Biomedicines · 2022Review
- Hippocampal functional connectivity across age in anFrontiers in aging neuroscience · 2022Article
- Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging.Frontiers in neuroscience · 2022Article
- Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study.Frontiers in aging neuroscience · 2021Article
- Monitoring Neuronal Network Disturbances of Brain Diseases: A Preclinical MRI Approach in the Rodent Brain.Frontiers in cellular neuroscience · 2021Review
- Topographical Visualization of the Reciprocal Projection between the Medial Septum and the Hippocampus in the 5XFAD Mouse Model of Alzheimer's Disease.International journal of molecular sciences · 2019Article
- Brain Network Connectivity and Executive Function in Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia.Brain connectivity · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Neurodegeneration in Alzheimer's disease (AD) is associated with amyloid-beta peptide accumulation into insoluble amyloid plaques. The five-familial AD (5XFAD) transgenic mouse model exhibits accelerated amyloid-beta deposition, neuronal dysfunction, and cognitive impairment. We aimed to determine whether connectome properties of these mice parallel those observed in patients with AD. We obtained diffusion tensor imaging and resting-state functional magnetic resonance imaging data for four transgenic and four nontransgenic male mice. We constructed both structural and functional connectomes and measured their topological properties by applying graph theoretical analysis. We compared connectome properties between groups using both binarized and weighted networks. Transgenic mice showed higher characteristic path length in weighted structural connectomes and functional connectomes at minimum density. Normalized clustering and modularity were lower in transgenic mice across the upper densities of the structural connectome. Transgenic mice also showed lower small-worldness index in higher structural connectome densities and in weighted structural networks. Hyper-correlation of structural and functional connectivity was observed in transgenic mice compared with nontransgenic controls. These preliminary findings suggest that 5XFAD mouse connectomes may provide useful models for investigating the molecular mechanisms of AD pathogenesis and testing the effectiveness of potential treatments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.