ArticleNetwork neuroscience (Cambridge, Mass.)2018
Heritability of the human connectome: A connectotyping study.
Article in Network neuroscience (Cambridge, Mass.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
80 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large-scale resting-state functional brain networks in aging.Psychophysiology · 2023Pooled it
- Cortical thickness as predictor of response to exercise in people with Parkinson's disease.Human brain mapping · 2021Trial
- Individualized Network Topography in Pre-adolescent Children and Adults Using Naturalistic Precision fMRI.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Unique local gradient-based functional fingerprints enable precisely identifying individual infants over ages.Developmental cognitive neuroscience · 2026Article
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- Exploration of Genetic Overlap of Brain Phenotypes With Schizophrenia: Different Methods Provide Complementary Insights.Schizophrenia bulletin · 2026Article
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- From Genetic Determinism to Epigenetic Regulation: Paradigm Shifts in the Understanding of Neurodevelopmental Disorders.Current issues in molecular biology · 2026Review
- Associations between amygdala connectivity and experienced discrimination in children.bioRxiv : the preprint server for biology · 2026Article
- Connectome-based symptom mapping and in silico related gene expression in children with autism and/or attention-deficit/hyperactivity disorder.Molecular psychiatry · 2026Article
- Article
- Multimodal identification of the mouse brain using simultaneous CaCommunications biology · 2025Article
- Innate network mechanisms of temporal pole for semantic cognition in neonatal and adult twin studies.Nature communications · 2025Article
- The control costs of human brain dynamics.Network neuroscience (Cambridge, Mass.) · 2025Article
- Genetic contribution to intrinsic functional connectivity underlying general intelligence: evidence from adult twin study.Brain communications · 2025Article
- Local Gradients of Functional Connectivity Enable Precise Fingerprinting of Infant Brains During Dynamic Development.bioRxiv : the preprint server for biology · 2024Article
- Connectome-based symptom mapping andmedRxiv : the preprint server for health sciences · 2024Article
- The promise of precision functional mapping for neuroimaging in psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Precision Functional Mapping to Advance Developmental Psychiatry Research.Biological psychiatry global open science · 2024Review
- Genetic fingerprinting with heritable phenotypes of the resting-state brain network topology.Communications biology · 2024Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Recent progress in resting-state neuroimaging demonstrates that the brain exhibits highly individualized patterns of functional connectivity-a "connectotype." How these individualized patterns may be constrained by environment and genetics is unknown. Here we ask whether the connectotype is familial and heritable. Using a novel approach to estimate familiality via a machine-learning framework, we analyzed resting-state fMRI scans from two well-characterized samples of child and adult siblings. First we show that individual connectotypes were reliably identified even several years after the initial scanning timepoint. Familial relationships between participants, such as siblings versus those who are unrelated, were also accurately characterized. The connectotype demonstrated substantial heritability driven by high-order systems including the fronto-parietal, dorsal attention, ventral attention, cingulo-opercular, and default systems. This work suggests that shared genetics and environment contribute toward producing complex, individualized patterns of distributed brain activity, rather than constraining local aspects of function. These insights offer new strategies for characterizing individual aberrations in brain function and evaluating heritability of brain networks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.