Evidence map›Paper›PMID 30214989›Full record

ReviewClinical neurophysiology practice2017

The role for ketogenic diets in epilepsy and status epilepticus in adults.

Tanya J Williams, Mackenzie C Cervenka

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical neurophysiology practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04358835 nawithdrawnnot on this mapstarted 2020, after this paper: background citation

Keto-diet for Intubated Critical Care COVID-19 (KICC-COVID19)

TypeinterventionalSponsorJohns Hopkins UniversityRan2020 to 2021Enrolled0ConditionsCOVID-19ArmsKetogenic diet, standard of care
NCT05219006 nacompletednot on this mapstarted 2021, after this paper: background citation

Ketogenic Diet Effects on the Frequency of Non Epileptic Seizures in Patients With Dissociative Neurological Symptom Disorder: a Pilot Study

TypeinterventionalSponsorEl Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco SuarezRan2021 to 2023Enrolled17ConditionsNon Epileptic Seizures, Functional Neurological Symptom Disorder, Conversion Disorder, Ketogenic DietingArmsketogenic dieting, healthy dieting
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.

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  20. Nutrients · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Tanya J WilliamsDepartment of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 2-147, Baltimore, MD, USA.
Mackenzie C CervenkaDepartment of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 2-147, Baltimore, MD, USA.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ketogenic diet (KD) therapies are high fat, low carbohydrate diets designed to mimic a fasting state. Although studies demonstrate KD's success in reducing seizures stretching back nearly a century, the last 25 years have seen a resurgence in diet therapy for the management of drug-resistant epilepsy in children as well as adults. With ≥50% seizure reduction efficacy rates in adults of 22-55% for the classic KD and 12-67% for the modified Atkins diet, diet therapy may be in many instances comparable to a trial of an additional anti-epileptic medication and potentially with fewer side effects and other health benefits. Moreover, ketogenic diets offer promising new adjunctive strategies for the treatment of acute status epilepticus in the intensive care setting. Here, we review the efficacy and utility of ketogenic diets for the management of chronic epilepsy and refractory status epilepticus in adults and offer practical guidelines for diet implementation and maintenance.

Indexed as

Drug-resistant epilepsyEpilepsyKetogenic dietModified Atkins dietRefractory status epilepticus

Identifiers

PMID30214989
PMCPMC6123874
OpenAlexW2731476017

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.