Evidence map›Paper›PMID 30214974›Full record

ArticleClinical neurophysiology practice2017

Visual evoked potentials after hematopoietic allogeneic stem cell transplantation in childhood.

Alba Lucia Törnquist, Thomas Andersson, Jacek Winiarski, Marita Andersson Grönlund, Kristina Teär Fahnehjelm

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Article in Clinical neurophysiology practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Alba Lucia TörnquistDepartment of Clinical Neuroscience, Karolinska Institutet and St Erik Eye Hospital, Polhemsgatan 50, SE 112 82 Stockholm, Sweden.
Thomas AnderssonDepartment of Clinical Neurophysiology, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
Jacek WiniarskiDepartment of Clintec, Karolinska Institutet, and Department of Paediatrics, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
Marita Andersson GrönlundDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Kristina Teär FahnehjelmDepartment of Clinical Neuroscience, Karolinska Institutet and St Erik Eye Hospital, Polhemsgatan 50, SE 112 82 Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo study visual pathway pathology detected by visual evoked potentials (VEPs) in patients treated with hematopoietic stem cell transplantation (HSCT) in childhood and to determine the impact of adverse ocular findings, somatic diseases, and conditioning regimens on the VEP results.

methodsOphthalmological assessments including pattern VEPs were performed in 47 of 79 patients at a median age of 15 years (range 3-21 years) in median 6 years (1-17 years) after HSCT. Somatic data were extracted from medical records.

resultsEight patients of 47 (17%) demonstrated pathological VEPs with prolonged latencies bilaterally (n = 3) or unilaterally (n = 5) at their latest VEP test at an age of 12-18 years. A subnormal visual acuity was present in 8/11 eyes with pathological VEPs: one eye had cataract, six eyes had cataract surgery where of two had developed secondary cataracts. One eye had residual retinopathy of prematurity. Pathological VEPs were associated with decreased visual acuity (p = 0.00019) but not linked to gender, malignant diagnosis or conditioning.

conclusionVEP recordings showed an association with decreased visual acuity but no relationship with irradiation or chemotherapy in the present study. SIGNIFICANCE: VEP recordings might be of clinical value for children with an unexplained subnormal visual acuity undergoing HSCT.

Indexed as

BCVA, best corrected visual acuityCI, cranial irradiationCNS, central nervous systemCT, computerized tomographyCyA, cyclosporine Af-TBI, fractionated total body irradiationGVHD, graft versus host diseaseHematopoietic stem cell transplantationHLA, human leukocyte antigenHSCT, hematopoietic stem cell transplantationIOL, intra ocular lensMRI, magnetic resonance imagingROP, retinopathy of prematuritys-TBI, single fractio total body irradiationTBI, total body irradiationVEP, visual evoked potentialsVisual acuityVisual evoked potentials

Identifiers

PMID30214974
PMCPMC6123843

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