ArticleScience advances2018
Frustration-induced phases in migrating cell clusters.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Galvanotactic directionality of cell groups depends on group size.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Optimal mechanical interactions direct multicellular network formation on elastic substrates.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Matrix obstructions cause multiscale disruption in collective epithelial migration by suppressing leader cell function.Molecular biology of the cell · 2023Article
- Curvature induces active velocity waves in rotating spherical tissues.Nature communications · 2023Article
- Collective rotational motion of freely expanding T84 epithelial cell colonies.Journal of the Royal Society, Interface · 2023Article
- Neighbor-enhanced diffusivity in dense, cohesive cell populations.PLoS computational biology · 2021Article
- Learning the dynamics of cell-cell interactions in confined cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Self-propelling and rolling of a sessile-motile aggregate of the bacterium Caulobacter crescentus.Communications biology · 2020Article
- Rules of collective migration: from the wildebeest to the neural crest.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Dynamic instability and migration modes of collective cells in channels.Journal of the Royal Society, Interface · 2019Article
- Collective gradient sensing and chemotaxis: modeling and recent developments.Journal of physics. Condensed matter : an Institute of Physics journal · 2018Review
- Bi-stability in cooperative transport by ants in the presence of obstacles.PLoS computational biology · 2018Article
- Switching between individual and collective motility in B lymphocytes is controlled by cell-matrix adhesion and inter-cellular interactions.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Certain malignant cancer cells form clusters in a chemoattractant gradient, which can spontaneously show three different phases of motion: translational, rotational, and random. Guided by our experiments on the motion of two-dimensional clusters in vitro, we developed an agent-based model in which the cells form a cohesive cluster due to attractive and alignment interactions. We find that when cells at the cluster rim are more motile, all three phases of motion coexist, in agreement with our observations. Using the model, we show that the transitions between different phases are driven by competition between an ordered rim and a disordered core accompanied by the creation and annihilation of topological defects in the velocity field. The model makes specific predictions, which we verify with our experimental data. Our results suggest that heterogeneous behavior of individuals, based on local environment, can lead to novel, experimentally observed phases of collective motion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.