ArticleFrontiers in medicine2018
Sun Exposure and Melanoma, Certainties and Weaknesses of the Present Knowledge.
Article in Frontiers in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Hypoxia-Inducible Factor-1α Gene (Cancers · 2026Article
- Regional Variations in Melanoma Histologic Characteristics: A Multicenter Cohort Study from Two Southeastern European Countries.Journal of clinical medicine · 2026Article
- Article
- Circulating tumor cells as biomarkers in melanoma: techniques, challenges, and clinical applications.Frontiers in cell and developmental biology · 2026Review
- Elucidating the role of medicinal plants in melanoma treatment: a review on metastatic progression and phytochemical intervention.Frontiers in pharmacology · 2026Review
- Severe Sunburns and Sunbed Use Risk with Cutaneous Melanoma: A Case-Control Study in Lithuania.Medicina (Kaunas, Lithuania) · 2025Article
- Melanoma in Northwestern Romania: An Analysis of Epidemiological and Histopathological Characteristics and Associated Risk Factors.Journal of clinical medicine · 2025Article
- Dual role of Cathepsin S in cutaneous melanoma: insights from mendelian randomization and bioinformatics analysis.BMC cancer · 2025Article
- Ambient ultraviolet A, ultraviolet B, and risk of melanoma in a nationwide United States cohort, 1984-2014.Journal of the National Cancer Institute · 2024Article
- Metastasis of malignant melanoma to the urinary bladder & descending colon: A case report and literature review.Urology case reports · 2024Article
- Nanoemulsified Essential Oil ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Recent-Onset Melanoma and the Implications of the Excessive Use of Tanning Devices-Case Report and Review of the Literature.Medicina (Kaunas, Lithuania) · 2024Review
- Sustained pigmentation causes DNA damage and invokes translesion polymerase Polκ for repair in melanocytes.Nucleic acids research · 2023Article
- Variability of Sentinel Lymph Node Location in Patients with Trunk Melanoma.Diagnostics (Basel, Switzerland) · 2023Article
- The Cross Talk between Cellular Senescence and Melanoma: From Molecular Pathogenesis to Target Therapies.Cancers · 2023Review
- Deciphering the Relationship between SARS-CoV-2 and Cancer.International journal of molecular sciences · 2023Review
- The evidence forTranslational cancer research · 2023Review
- Editorial: Beyond ultraviolet B radiation: exploring the impact of UVA on skin, reappraisal of UVA phototherapy, and advances in UVA-damage prevention.Frontiers in medicine · 2023Article
- Suppression of CaThe EMBO journal · 2022Article
- Carotenoids from Marine Microalgae as Antimelanoma Agents.Marine drugs · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sun exposure is the main risk factor for cutaneous malignant melanoma (CMM). However, the UV-related pathogenetic mechanisms leading to CMM are far to be fully elucidated. In this paper we will focus on what we still don't fully know about the relationship between UVR and CMM. In particular, we will discuss: the action spectrum of human CMM, how different modalities of exposure (continuous/ intermittent; erythemal/ suberythemal) relate to different CMM variants, the preferential UVR induced DNA mutations observed in different CMM variants, the role of UV-related and UV-unrelated genetic damages in the same melanoma cells. Moreover, we will debate the importance of UVA induced oxidative and anaerobic damages to DNA and other cell structures and the role of melanins, of modulation of innate and acquired immunity, of vitamin D and of chronic exposure to phototoxic drugs and other xenobiotics. A better understanding of these issues will help developing more effective preventative strategies and new therapeutic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.