Evidence map›Paper›PMID 30214860›Full record

ArticleCardiovascular diagnosis and therapy2018

Arterial stiffness in black African ancestry patients with chronic kidney disease living in Cameroon.

Daniel Lemogoum, Marie Patrice Halle, Ruth Dione Mboule, Philippe Van de Borne, Elysée Claude Bika Lele, Felicité Kamdem, Marie Solange Doualla, Henry Luma, Michel P Hermans, Luc Van Bortel

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Article in Cardiovascular diagnosis and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Daniel LemogoumFaculty of medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon.
Marie Patrice HalleFaculty of medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon.
Ruth Dione MbouleFaculty of medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon.
Philippe Van de BorneULB-Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Elysée Claude Bika LeleCameroon Heart Foundation, Douala, Cameroon.
Felicité KamdemFaculty of medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon.
Marie Solange DouallaDepartment of Internal Medicine, Douala General Hospital, Douala, Cameroon.
Henry LumaDepartment of Internal Medicine, Douala General Hospital, Douala, Cameroon.
Michel P HermansEndocrinology and Nutrition Unit, Cliniques Universitaires St-Luc, Université Catholique de Louvain, Avenue Hippocrate, Brussels, Belgium.
Luc Van BortelHeymans Institute of Pharmacology, Ghent University, Ghent, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreased aortic pulse wave velocity (PWV), a direct measure of arterial stiffness (AS) is an independent predictor of cardiovascular events (CVEs) in chronic kidney disease (CKD) patients. This study assessed the patterns of PWV among Cameroonian patients with CKD in whom that marker of early vascular aging has not been explored so far.

methodsWe enrolled 150 Black African patients (mean age: 52±15 years, 56.7% males) with CKD in a cross-sectional study conducted at Douala General Hospital, Douala, Cameroon. Sociodemographic, anthropometric and biologic variables, blood pressure (BP) and PWV were recorded in all participants. Estimated aortic PWV was measured using a Mobil-O-Graph automatic brachial oscillometric device.

resultsPWV increased with aging (P<0.0001), and PWV adjusted for age, sex, body mass index and mean arterial BP (MAP) was higher in non-dialysed (n=90) than in hemodialysed (n=60) patients, even in pre-dialysis: 8.5±2.0

conclusionsOur findings suggest increased AS in Cameroonian CKD non-dialyzed as compared to dialyzed patients. Slower PWV in patients on maintenance hemodialysis suggests improvement of aortic distensibility following dialysis. However, further large-scale studies are needed to confirm our findings and to improve understanding of the underlying mechanisms of arterial stiffening in black African ancestry patients with CKD.

Indexed as

Arterial stiffness (AS)Cameroonchronic kidney disease (CKD)hemodialysisMobil-O-graphpulse wave velocity (PWV)

Identifiers

PMID30214860
PMCPMC6129837

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