ArticleCardiovascular diagnosis and therapy2018
Non-cardiac comorbidities in adults with inherited and congenital heart disease: report from a single center experience of more than 800 consecutive patients.
Article in Cardiovascular diagnosis and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Congenital Heart Defects and Mental Health: Stress, Psychological Treatment Use, and COVID-19-Related Burden in Young Patients-Lessons from the P-BAHn Study.Journal of clinical medicine · 2026Article
- Body plethysmography - additional information on exercise capacity in patients with congenital heart disease?Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Genetic Syndromes and Multimorbidity in Adults with Congenital Heart Disease and Heart Failure: Insights from the PATHFINDER-CHD Registry.Journal of clinical medicine · 2026Article
- Comorbidity and Multimorbidity in Adults With Congenital Heart Disease: Findings From a Multi-Site Population-Based Study.Birth defects research · 2025Article
- [Transition in patients with congenital heart disease].Innere Medizin (Heidelberg, Germany) · 2025Review
- Perioperative Risk in Adults with Congenital Heart Disease Undergoing Non-Cardiac Surgery: Challenges and Tailored Strategies.Journal of clinical medicine · 2025Review
- Psychiatric and Psychological Implications of Congenital Heart Disease.Journal of clinical medicine · 2025Review
- Anaesthesia for children with congenital heart disease undergoing non-cardiac surgery.BJA education · 2024Review
- Pulmonary hypertension in adults with congenital heart defects (ACHDs)-in light of the 2022 ESC PAH guidelines-part I: definition, epidemiology, classification, diagnostics, genetics, risk stratification and follow-up, gender aspects.Cardiovascular diagnosis and therapy · 2024Review
- Continuous Long-Term Assessment of Heart Rate Variability in Adults with Cyanotic Congenital Heart Disease after Surgical Repair.Journal of clinical medicine · 2024Article
- PATHFINDER-CHD: prospective registry on adults with congenital heart disease, abnormal ventricular function, and/or heart failure as a foundation for establishing rehabilitative, prehabilitative, preventive, and health-promoting measures: rationale, aims, design and methods.BMC cardiovascular disorders · 2024Article
- Thymic Atrophy and Immune Dysregulation in Infants with Complex Congenital Heart Disease.Journal of clinical immunology · 2024Article
- Introduction to the focused series on "Current Management Aspects in Adult Congenital Heart Disease (ACHD): Part V".Cardiovascular diagnosis and therapy · 2023Article
- Significantly increased risk of chronic obstructive pulmonary disease amongst adults with predominantly mild congenital heart disease.Scientific reports · 2022Article
- Long-term course of pulmonary arterial hypertension in adults with congenital heart disease under targeted therapy: a retrospective analysis of a single tertiary center.Cardiovascular diagnosis and therapy · 2022Article
- Liver parenchymal changes and association with cardiac magnetic resonance imaging findings in repaired tetralogy of Fallot: an intravoxel incoherent motion magnetic resonance imaging study.Pediatric radiology · 2022Article
- Infective endocarditis and oral health-a Narrative Review.Cardiovascular diagnosis and therapy · 2021Review
- The utility of preoperative echocardiography in pediatric obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2021Article
- Endangered patients with congenital heart defect during transition-Germany-wide evaluation of medical data from National Register for Congenital Heart Defects (NRCHD).Cardiovascular diagnosis and therapy · 2021Article
- Different levels of care for follow-up of adults with congenital heart disease: a cost analysis scrutinizing the impact on medical costs, hospitalizations, and emergency department visits.The European journal of health economics : HEPAC : health economics in prevention and care · 2021Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs a result of improved surgical and therapeutical management, more than 90% of patients with congenital heart disease (CHD) reach adulthood. However, the natural course of CHD is complicated by noncardiac medical problems. Aim of the study was to evaluate noncardiac comorbidities in a contemporary cohort of adults with CHD (ACHD).
methodsIn a tertiary care center for ACHD, 821 consecutive patients, admitted to the outpatient clinic, were evaluated for clinically relevant noncardiac comorbidities.
resultsThe consecutively included patients (age: range, 15-80 years; 56% female) represent all types and severity grades of acyanotic and cyanotic CHD. A considerable proportion of ACHD had significant noncardiac comorbidities, which have the potential to profoundly influence the natural course of the underlying disease. In 95.5%, relevant non-cardiac comorbidities were apparent, that could be related to 16 special medical fields as endocrinologic/metabolic disease, gastroenterology/hepatology, gynecology/obstetrics, angiology, orthopedics, neurology/psychiatry and others. Most frequently seen comorbidities were endocrine and metabolic disorders (43.97%).
conclusionsNon-cardiac comorbidities are increasingly common in ACHD. The data revealed non-cardiac comorbidities as they were presented in the cohort of ACHD seen in a tertiary center. The study proves that ACHD with significant non-cardiac comorbidities need multidisciplinary care by medical organ specialists, aside the congenital cardiologist, with a deep knowledge about congenital heart defects, the special effects of the organ disease on the particular heart defect and, how the heart defect may affect the course of the particular organ disease. The study may create the basis for the development of screening programs for comorbidities in ACHD as well as a multidisciplinary concept for diagnosis and treatment of concomitant disorders or for disease prevention. Particularly disease prevention may improve quality of life as well as the further fate of the affected patients.
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