ReviewCureus2018
The Role of Vitamin D in Brain Health: A Mini Literature Review.
Review in Cureus, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 5 syntheses or guidelines pooled it, 181 citations in OpenAlex.
- Vitamin deficiency, a neglected risk factor for post-anesthesia complications: a systematic review.European journal of medical research · 2025Pooled it
- Pooled it
- Nutritional interventions to support acute mTBI recovery.Frontiers in nutrition · 2022Pooled it
- Vitamin D in migraine headache: a comprehensive review on literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Pooled it
- Vitamin D deficiency as a risk factor for dementia and Alzheimer's disease: an updated meta-analysis.BMC neurology · 2019Pooled it
- Trial
- Effect of vitamin D supplementation on depression in older Australian adults.International journal of geriatric psychiatry · 2023Trial
- Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Trial
- Peripheral BDNF-TrkB Expression and Vitamin D Status in Depression, Prediabetes and Type 2 Diabetes: A Cross-Sectional Biomarker Study.Biomedicines · 2026Article
- Multiple organ dysfunction syndrome: molecular mechanisms and therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Vitamin D concentrations and headache risk in children and adolescents aged 6 to 19 years: The mediating role of body mass index.Medicine · 2026Article
- Neurobiological mechanisms linking vitamin d signaling to cognitive decline and neurodegeneration: Untangling epidemiology, pathophysiology, and evidence.World journal of experimental medicine · 2026Review
- Neurobiophilia.Brain sciences · 2026Review
- Can Myokines Serve as Supporters of Muscle-Brain Connectivity in Obesity and Type 2 Diabetes? Potential of Exercise and Nutrition Interventions.Nutrients · 2025Review
- Article
- Invisible Links: Associations Between Micronutrient Deficiencies and Postpartum Depression-A Systematic Review.Life (Basel, Switzerland) · 2025Review
- Neuroprotective Roles of Vitamin D: Bridging the Gap Between Mechanisms and Clinical Applications in Cognitive Decline.International journal of molecular sciences · 2025Review
- Vitamin D and brain volumetric changes: An updated systematic review and meta-analysis.IBRO neuroscience reports · 2025Article
- Electrochemiluminescent/colorimetric monitoring 25(OH)DMikrochimica acta · 2025Article
- The Sunshine Paradox: Unraveling Risk Factors for Low Vitamin D Status Among Non-Pregnant Women in Lebanon.Nutrients · 2025Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D is vital for our body as it regulates calcium homeostasis and maintains bone integrity. In this article, we will discuss how vitamin D aids in the function of neuronal and glial tissue and the many health consequences in a person with vitamin D deficiency. Some of the effects of vitamin D deficiency that will be discussed include the development of dementia caused by the increase of cerebral soluble and insoluble amyloid-β (Aβ) peptides and a decrease of its anti-inflammatory/antioxidant properties, the link to depression by a reduction of the buffering of increased calcium in the brain, and vitamin D deficiency in expecting mothers linking to the development of autism and schizophrenic-like disorders, hypoxic brain injury, and other mental illnesses. Lastly, we will discuss how vitamin D deficiency is linked to the development of diabetes mellitus, its role in neuronal development and a decrease of microglial inflammatory function leading to increased brain infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.