Evidence map›Paper›PMID 30214632›Full record

ArticleTheranostics2018

Radionuclide imaging of VEGFR2 in glioma vasculature using biparatopic affibody conjugate: proof-of-principle in a murine model.

Bogdan Mitran, Rezan Güler, Francis P Roche, Elin Lindström, Ram Kumar Selvaraju, Filippa Fleetwood, Sara S Rinne, Lena Claesson-Welsh, Vladimir Tolmachev, Stefan Ståhl and 2 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  3. Preclinical evaluation and preliminary clinical study ofCancer imaging : the official publication of the International Cancer Imaging Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Bogdan MitranDepartment of Medicinal Chemistry, Uppsala University, Sweden.
Rezan GülerDepartment of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Sweden.
Francis P RocheDepartment of Immunology, Genetics and Pathology, Uppsala University, Sweden.
Elin LindströmDepartment of Medicinal Chemistry, Uppsala University, Sweden.
Ram Kumar SelvarajuDepartment of Medicinal Chemistry, Uppsala University, Sweden.
Filippa FleetwoodDepartment of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Sweden.
Sara S RinneDepartment of Medicinal Chemistry, Uppsala University, Sweden.
Lena Claesson-WelshDepartment of Immunology, Genetics and Pathology, Uppsala University, Sweden.
Vladimir TolmachevDepartment of Immunology, Genetics and Pathology, Uppsala University, Sweden.
Stefan StåhlDepartment of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Sweden.
Anna OrlovaDepartment of Medicinal Chemistry, Uppsala University, Sweden.
John LöfblomDepartment of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Sweden.
Uppsala University · SEKTH Royal Institute of Technology · SEScience for Life Laboratory · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular endothelial growth factor receptor-2 (VEGFR2) is a key mediator of angiogenesis and therefore a promising therapeutic target in malignancies including glioblastoma multiforme (GBM). Molecular imaging of VEGFR2 expression may enable patient stratification for antiangiogenic therapy. The goal of the current study was to evaluate the capacity of the novel anti-VEGFR2 biparatopic affibody conjugate (Z

Indexed as

AnimalsAntibodiesCell LineEndothelial CellsGliomaMiceMolecular ImagingProof of Concept StudyRadiopharmaceuticalsRecombinant Fusion ProteinsSensitivity and SpecificitySingle Photon Emission Computed Tomography Computed TomographyVascular Endothelial Growth Factor Receptor-2AntibodiesKdr protein, mouseRadiopharmaceuticalsRecombinant Fusion ProteinsVascular Endothelial Growth Factor Receptor-2affibody moleculein vivomolecular imagingorthotopic glioma modelSPECTVEGFR2

Identifiers

PMID30214632
PMCPMC6134937
OpenAlexW2886151851

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.