ArticleObstetric medicine2018
Physiological changes of pregnancy and the Swansea criteria in diagnosing acute fatty liver of pregnancy.
Article in Obstetric medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Safety and efficacy of plasmapheresis in treatment of acute fatty liver of pregnancy-a systematic review and meta-analysis.Frontiers in medicine · 2024Pooled it
- Acute fatty liver of pregnancy in the context of normal-dose acetaminophen exposure: a case report.BMC pregnancy and childbirth · 2026Article
- Liver Biopsy During Pregnancy: A Review.Cureus · 2025Review
- Plasmapheresis for Suspected Drug-Induced Liver Injury During Pregnancy: A Multidisciplinary Diagnostic and Therapeutic Challenge.Journal of clinical medicine · 2025Review
- Menace of hepatitis E in pregnancy: unleashing the threat of fulminant liver failure.BMJ case reports · 2024Article
- Hepatic encephalopathy precipitated by preeclampsia in the setting of cirrhosis: A case report.Case reports in women's health · 2024Article
- Investigating gastrointestinal disorders in pregnancy.Obstetric medicine · 2024Review
- A 24-Year-Old Woman Presenting in the Third Trimester of Pregnancy with Nausea, Vomiting, and Abdominal Pain and Diagnosed with Acute Fatty Liver of Pregnancy.The American journal of case reports · 2022Article
- Swansea criteria score in acute fatty liver of pregnancy.Chinese medical journal · 2022Article
- Liver Diseases in the Parturient.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Acute Fatty Liver of Pregnancy.The American journal of case reports · 2021Article
- Prenatal Noninvasive Trio-WES in a Case of Pregnancy-Related Liver Disorder.Diagnostics (Basel, Switzerland) · 2021Article
- Accurate Prediction of Total PlGF (Placental Growth Factor) From Free PlGF and sFlt-1 (Soluble Fms-Like Tyrosine Kinase-1): Evidence for Markedly Elevated PlGF Levels in Women With Acute Fatty Liver of Pregnancy.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Two Fatty Liver Conditions Masquerading as Autoimmune Hepatitis.Case reports in hepatology · 2021Article
- Acute Kidney Injury in Pregnancies Complicated With Preeclampsia or HELLP Syndrome.Frontiers in medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Swansea criteria are used to assess the likelihood of acute fatty liver of pregnancy. There are significant physiological changes in normal pregnancy in several of the pathology parameters used in the Swansea criteria. This may impact the sensitivity and specificity of the Swansea criteria. Five of the 11 case series reporting laboratory values in acute fatty liver of pregnancy used values divergent from the Swansea criteria. When using the Swansea criteria for diagnosis of acute fatty liver of pregnancy, using pregnancy-specific and/or laboratory-specific reference intervals is recommended. Simpler diagnostic criteria using parameters of hepatocellular damage and hepatic synthetic dysfunction may be an alternative to the Swansea criteria, and further studies investigating the sensitivity and specificity of these parameters would be useful.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.