ArticleFrontiers in systems neuroscience2018
Positive Connectivity Predicts the Dynamic Intrinsic Topology of the Human Brain Network.
Article in Frontiers in systems neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Node persistence from topological data analysis reveals changes in brain functional connectivity.Patterns (New York, N.Y.) · 2026Article
- Relationships between brain functional connectivity and resting cardiac autonomic profiles in functional neurological disorder: A pilot study.NeuroImage. Clinical · 2026Article
- Structural and functional attention network connectivity in relation to visual selective attention dysfunction in cerebral visual impairment.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Delineating network integration and segregation in the pathophysiology of functional neurological disorder.Brain communications · 2025Article
- Graph analysis of guilt processing network highlights links with subclinical anxiety and self-blame.Social cognitive and affective neuroscience · 2024Article
- Age-related vulnerability of the human brain connectome.Molecular psychiatry · 2023Article
- A comparison of the functional connectome in mild traumatic brain injury and post-traumatic stress disorder.Human brain mapping · 2023Article
- Creativity at rest: Exploring functional network connectivity of creative experts.Network neuroscience (Cambridge, Mass.) · 2023Article
- Intentionality of Self-Generated Thought: Contributions of Mind Wandering to Creativity.Creativity research journal · 2023Article
- Neurogenetics of Dynamic Connectivity Patterns Associated With Obsessive-Compulsive Symptoms in Healthy Children.Biological psychiatry global open science · 2022Article
- Cerebro-cerebellar motor networks in clinical subtypes of Parkinson's disease.NPJ Parkinson's disease · 2022Article
- Neurogenetic traits outline vulnerability to cortical disruption in Parkinson's disease.NeuroImage. Clinical · 2022Article
- Early-life trauma endophenotypes and brain circuit-gene expression relationships in functional neurological (conversion) disorder.Molecular psychiatry · 2021Article
- The cross-sectional interplay between neurochemical profile and brain connectivity.Human brain mapping · 2021Article
- The functional connectome in posttraumatic stress disorder.Neurobiology of stress · 2021Article
- Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain.Frontiers in human neuroscience · 2021Article
- Large-scale resculpting of cortical circuits in children after surgical resection.Scientific reports · 2020Article
- Distance disintegration delineates the brain connectivity failure of Alzheimer's disease.Neurobiology of aging · 2020Article
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Authors and funding
7 authors.
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Abstract
Functional connectivity MRI (fcMRI) has become instrumental in facilitating research of human brain network organization in terms of coincident interactions between positive and negative synchronizations of large-scale neuronal systems. Although there is a common agreement concerning the interpretation of positive couplings between brain areas, a major debate has been made in disentangling the nature of negative connectivity patterns in terms of its emergence in several methodological approaches and its significance/meaning in specific neuropsychiatric diseases. It is still not clear what information the functional negative correlations or connectivity provides or how they relate to the positive connectivity. Through implementing stepwise functional connectivity (SFC) analysis and studying the causality of functional topological patterns, this study aims to shed light on the relationship between positive and negative connectivity in the human brain functional connectome. We found that the strength of negative correlations between voxel-pairs relates to their positive connectivity path-length. More importantly, our study describes how the spatio-temporal patterns of positive connectivity explain the evolving changes of negative connectivity over time, but not the other way around. This finding suggests that positive and negative connectivity do not display equivalent forces but shows that the positive connectivity has a dominant role in the overall human brain functional connectome. This phenomenon provides novel insights about the nature of positive and negative correlations in fcMRI and will potentially help new developments for neuroimaging biomarkers.
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