Evidence map›Paper›PMID 30214319›Full record

ArticleInternational journal of women's health2018

Diet-induced vitamin D deficiency triggers inflammation and DNA damage profile in murine myometrium.

Heba Elhusseini, Hoda Elkafas, Mohamed Abdelaziz, Sunil Halder, Ihor Atabiekov, Noura Eziba, Nahed Ismail, Abdeljabar El Andaloussi, Ayman Al-Hendy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of women's health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 41 citations in OpenAlex.

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  14. Non-hormonal mediators of uterine fibroid growth.Current opinion in obstetrics & gynecology · 2020
    Review
  15. Modulating effect of vitamin D3 on the mutagenicity and carcinogenicity of doxorubicin in Drosophila melanogaster and in silico studies.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Heba ElhusseiniDepartment of Obstetrics and Gynecology, University of Illinois of Chicago, Chicago, IL, USA, aelandal@uic.edu; aalhendy@uic.edu.
Hoda ElkafasDepartment of Obstetrics and Gynecology, University of Illinois of Chicago, Chicago, IL, USA, aelandal@uic.edu; aalhendy@uic.edu.
Mohamed AbdelazizDepartment of Obstetrics and Gynecology, Mansoura University Hospital, Mansoura Faculty of Medicine, Mansoura, Egypt.
Sunil HalderDepartment of Obstetrics and Gynecology, University of Illinois of Chicago, Chicago, IL, USA, aelandal@uic.edu; aalhendy@uic.edu.
Ihor AtabiekovDepartment of Obstetrics and Gynecology, University of Illinois of Chicago, Chicago, IL, USA, aelandal@uic.edu; aalhendy@uic.edu.
Noura EzibaDepartment of Obstetrics and Gynecology, University of Illinois of Chicago, Chicago, IL, USA, aelandal@uic.edu; aalhendy@uic.edu.
Nahed IsmailClinical Microbiology Division, University of Illinois of Chicago, Chicago, IL, USA.
Abdeljabar El AndaloussiDepartment of Obstetrics and Gynecology, University of Illinois of Chicago, Chicago, IL, USA, aelandal@uic.edu; aalhendy@uic.edu.
Ayman Al-HendyDepartment of Obstetrics and Gynecology, University of Illinois of Chicago, Chicago, IL, USA, aelandal@uic.edu; aalhendy@uic.edu.
University of Illinois Chicago · USMansoura University Hospital · EG

Funding

Hypovitaminosis D promotes MED12-associated genomic instability in uterine fibroidsR01HD094378 · NICHD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI AL-HENDY, AYMAN, BOYER, THOMAS G · 2018 to 2022
$4.2M
NICHD NIH HHS R01 HD094378
6 · The paper itself

Abstract

backgroundPreviously, we reported a significantly higher prevalence of uterine fibroids (UFs) in African American women. This minority group also commonly suffers from vitamin D deficiency. We have demonstrated that 1,25(OH) MATERIALS AND

methodsOur model of vitamin D lacking function was established using 8-week exposure of C57/BL6 mice to vitamin D-deficient diet provides evidence of different functions accomplished by vitamin D in the regulation of myometrium homeostasis disrupted in the context of uterine fibroid.

resultsWe found that vitamin D deficiency was associated with increased expression of sex steroid receptors in murine myometrium, increased expression of proliferation related genes, the promotion of fibrosis and enhanced inflammation, and promoted immunosuppression through Tregs expansion in murine myometrium. We also showed that a vitamin D deficient diet enhanced DNA damage in murine myometrium.

conclusionOur model mimics the effects in humans that a lack of vitamin D has and propels the study of in vivo interaction between inflammation, genomic instability and cell proliferation in the myometrium.

Indexed as

dietDNA damageinflammationuterine fibroidsvitamin D

Identifiers

PMID30214319
PMCPMC6120572
OpenAlexW2889233308

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.