Evidence map›Paper›PMID 30214236›Full record

ArticleOncoTargets and therapy2018

E2F3 promotes cancer growth and is overexpressed through copy number variation in human melanoma.

Zhicai Feng, Cheng Peng, Daojiang Li, Danhua Zhang, Xu Li, Fengran Cui, Yanhong Chen, Quanyong He

Open access · goldAbstract read
In one paragraph

Article in OncoTargets and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

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  20. miR-378a-5p and miR-630 induce lens epithelial cell apoptosis in cataract via suppression of E2F3.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Zhicai FengDepartment of Burns and Plastic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China, qyonghe@126.com.
Cheng PengDepartment of Burns and Plastic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China, qyonghe@126.com.
Daojiang LiDepartment of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Danhua ZhangDepartment of Medical Laboratory, Huakang Hospital, Dazhou, Sichuan, China.
Xu LiDepartment of Burns and Plastic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China, qyonghe@126.com.
Fengran CuiDepartment of Burns and Plastic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China, qyonghe@126.com.
Yanhong ChenFujian Medical University, Fuzhou, Fujian, China.
Quanyong HeDepartment of Burns and Plastic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China, qyonghe@126.com.
Central South University · CNDazhou Central Hospital · CNFujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMelanoma is a malignant tumor that seriously affects patients. The pathogenesis of malignant melanoma is complex, and the cell cycle is closely related to tumor progression. Based on the catalog of cancer somatic mutations, we found that overexpression of the METHODS AND

resultsWe found that

conclusionIt can be speculated that copy number amplification and other mechanisms result in the high expression of

Indexed as

copy numberE2F3mechanismmelanomamethylationoverexpression

Identifiers

PMID30214236
PMCPMC6124799
OpenAlexW2889300147

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.