Evidence map›Paper›PMID 30214202›Full record

ArticleInternational journal of nanomedicine2018

Chitosan-polyvinyl alcohol nanoscale liquid film-forming system facilitates MRSA-infected wound healing by enhancing antibacterial and antibiofilm properties.

Sha Yang, Yun Yang, Sixin Cui, Ziqi Feng, Yuzhi Du, Zhen Song, Yanan Tong, Liuyang Yang, Zelin Wang, Hao Zeng and 2 more

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Chitosan-Based Antibacterial Films for Biomedical and Food Applications.International journal of molecular sciences · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Rational selection of antifungal drugs to propose a new formulation strategy to control Candida biofilm formation on venous catheters.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020
    Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sha YangNational Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University of Chinese PLA, Chongqing, 400038, People's Republic of China, qmzou2007@163.com; sunhongwu2001@163.com.
Yun YangNational Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University of Chinese PLA, Chongqing, 400038, People's Republic of China, qmzou2007@163.com; sunhongwu2001@163.com.
Sixin CuiNational Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University of Chinese PLA, Chongqing, 400038, People's Republic of China, qmzou2007@163.com; sunhongwu2001@163.com.
Ziqi FengNational Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University of Chinese PLA, Chongqing, 400038, People's Republic of China, qmzou2007@163.com; sunhongwu2001@163.com.
Yuzhi DuNational Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University of Chinese PLA, Chongqing, 400038, People's Republic of China, qmzou2007@163.com; sunhongwu2001@163.com.
Zhen SongNational Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University of Chinese PLA, Chongqing, 400038, People's Republic of China, qmzou2007@163.com; sunhongwu2001@163.com.
Yanan TongNational Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University of Chinese PLA, Chongqing, 400038, People's Republic of China, qmzou2007@163.com; sunhongwu2001@163.com.
Liuyang YangNational Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University of Chinese PLA, Chongqing, 400038, People's Republic of China, qmzou2007@163.com; sunhongwu2001@163.com.
Zelin WangNational Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University of Chinese PLA, Chongqing, 400038, People's Republic of China, qmzou2007@163.com; sunhongwu2001@163.com.
Hao ZengNational Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University of Chinese PLA, Chongqing, 400038, People's Republic of China, qmzou2007@163.com; sunhongwu2001@163.com.
Quanming ZouNational Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University of Chinese PLA, Chongqing, 400038, People's Republic of China, qmzou2007@163.com; sunhongwu2001@163.com.
Hongwu SunNational Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University of Chinese PLA, Chongqing, 400038, People's Republic of China, qmzou2007@163.com; sunhongwu2001@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMethicillin-resistant

methodsIn this study, a novel nanoscale liquid film-forming system (LFFS) loaded with benzalkonium bromide was produced based on polyvinyl alcohol and chitosan.

resultsThis LFFS showed a faster and more potent effect against MRSA252 than benzalkonium bromide aqueous solution both in vitro and in vivo. Additionally, the LFFS had a stronger ability to destroy biofilms (5 mg/mL) and inhibit their formation (1.33 μg/mL). The LFFS inflicted obvious damage to the structure and integrity of MRSA cell membranes and caused increases in the release of alkaline phosphate and lactate dehydrogenase in the relative electrical conductivity and in K

conclusionThe novel LFFS is promising as an effective system for disinfectant delivery and for application in the treatment of MRSA wound infections.

Indexed as

BiofilmsAnimalsAnti-Bacterial AgentsCell MembraneChitosanDrug LiberationFemaleHumansMethicillin-Resistant Staphylococcus aureusMice, Inbred BALB CMicrobial Sensitivity TestsNanoparticlesPolyvinyl AlcoholWound HealingAnti-Bacterial AgentsChitosanPolyvinyl Alcoholantibacterialantibiofilmliquid film-forming systemmethicillin-resistant Staphylococcus aureuswound healing

Identifiers

PMID30214202
PMCPMC6128272

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.