ArticleIranian journal of medical sciences2018
Human Amniotic Membrane Effect on Perianal Fistula Healing in Rabbits: An Experimental Study.
Article in Iranian journal of medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Decellularized Persian walnut leaf (Frontiers in bioengineering and biotechnology · 2025Article
- Human Amniotic Membrane for the Treatment of Cryptoglandular Anal Fistulas.Journal of clinical medicine · 2022Article
- Anal Fistula Human Amniotic Membrane Endosealing (F-HAME): A Proof of Concept Study.Frontiers in surgery · 2022Article
- Adipose-Derived Stem Cells Are an Efficient Treatment for Fistula-in-ano of Japanese Rabbit.Stem cells international · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPerianal fistula is a complicated disorder and most difficult to manage. New treatment methods would help surgeons to achieve a better outcome in patients with perianal fistula. Human amniotic membrane (HAM) has positive effects on wound healing in several conditions. The present study aimed to further determine the effect of HAM on wound healing of perianal fistula in rabbits.
methodsIn a prospective experimental study, 14 male rabbits (aged 4-6 months and weighing 3-4 kg) were randomly divided into 2 groups. After 12 weeks, the high type perianal fistula was repaired with endorectal flap (ERF) and ERF plus HAM in the control and case groups, respectively. In all rabbits of the case group, a 1×1 cm width wrap of HAM was applied and fixed around the ERF site. Three weeks later, the repaired site of the perianal fistula was sent for pathologic wound healing scoring. The results were analyzed with the SPSS 21.0 software using Mann-Whitney test.
resultsSix rabbits of each group survived the study period. There was a statistically significant difference in wound healing between the case and control groups (P<0.001). Wound healing process in the case group occurred better and faster than the control group.
conclusionHAM has an effective role in enhancing the ERF procedure and considered appropriate. A combination of HAM with other methods is recommended.
Indexed as
Identifiers
30214099PMC6123562W2793022996What OpenQuestion holds
Registered trials
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