Evidence map›Paper›PMID 30213987›Full record

ArticleScientific reports2018

A comprehensive manually-curated compendium of bovine transcription factors.

Marcela M de Souza, Adhemar Zerlotini, Ludwig Geistlinger, Polyana C Tizioto, Jeremy F Taylor, Marina I P Rocha, Wellison J S Diniz, Luiz L Coutinho, Luciana C A Regitano

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Genome-wide insights into selection signatures for transcription factor binding sites in cattle ROH regions.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Article
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  6. Genome and Transcriptome-Wide Analysis ofInternational journal of molecular sciences · 2022
    Article
  7. EEF1A1 transcription cofactor gene polymorphism is associated with muscle gene expression and residual feed intake in Nelore cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2022
    Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marcela M de SouzaPost-graduation Program of Evolutionary Genetics and Molecular Biology, Federal University of São Carlos, São Carlos, São Paulo, 13560-970, Brazil.
Adhemar ZerlotiniBioinformatic Multi-user Laboratory, Embrapa Informática Agropecuária, Campinas, São Paulo, 70770-901, Brazil.ORCID 0000-0002-7739-0284
Ludwig GeistlingerAnimal Biotechnology, Embrapa Pecuária Sudeste, São Carlos, São Paulo, 13560-970, Brazil.
Polyana C TiziotoNGS Genomic Solutions, Piracicaba, São Paulo, Brazil.
Jeremy F TaylorDivision of Animal Science, University of Missouri, Columbia, Missouri, 65211-5300, USA.ORCID 0000-0002-6997-7245
Marina I P RochaPost-graduation Program of Evolutionary Genetics and Molecular Biology, Federal University of São Carlos, São Carlos, São Paulo, 13560-970, Brazil.
Wellison J S DinizPost-graduation Program of Evolutionary Genetics and Molecular Biology, Federal University of São Carlos, São Carlos, São Paulo, 13560-970, Brazil.ORCID 0000-0003-1082-5535
Luiz L CoutinhoFunctional Genomic Center, University of São Paulo, Piracicaba, São Paulo, 13418-900, Brazil.ORCID 0000-0002-7266-8881
Luciana C A RegitanoAnimal Biotechnology, Embrapa Pecuária Sudeste, São Carlos, São Paulo, 13560-970, Brazil. luciana.regitano@embrapa.br.ORCID 0000-0001-9242-8351

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcription factors (TFs) are pivotal regulatory proteins that control gene expression in a context-dependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an improved comprehension of regulatory mechanisms that are specific to the species.

Indexed as

Databases, GeneticAnimalsCattleDNA-Binding ProteinsGene Expression RegulationHumansTranscription FactorsDNA-Binding ProteinsTranscription Factors

Identifiers

PMID30213987
PMCPMC6137171

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.