ArticleScientific reports2018
Geobiology reveals how human kidney stones dissolve in vivo.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
- ePHex: a phase 3, double-blind, placebo-controlled, randomized study to evaluate long-term efficacy and safety of Oxalobacter formigenes in patients with primary hyperoxaluria.Pediatric nephrology (Berlin, Germany) · 2023Trial
- Intercalated bacterial biofilms are intrinsic internal components of calcium-based kidney stones.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mechanisms of osteopontin-stabilized amorphous calcium phosphate calcification in benign and pre-malignant breast disease.Scientific reports · 2025Article
- Kidney Stones as Minerals: How Methods from Geology Could Inform Urolithiasis Treatment.Journal of clinical medicine · 2025Review
- Ab Initio Molecular Dynamics Simulations of Phosphocholine Interactions with a Calcium Oxalate Dihydrate (110) Surface.Crystal growth & design · 2024Article
- Risk Factors of Asymptomatic Kidney Stone Passage in Adults with Recurrent Kidney Stones.Clinical journal of the American Society of Nephrology : CJASN · 2024Article
- Osteopontin stabilization and collagen containment slows amorphous calcium phosphate transformation during human aortic valve leaflet calcification.Scientific reports · 2024Article
- Kidney stone growth through the lens of Raman mapping.Scientific reports · 2024Article
- The impact of crystal phase transition on the hardness and structure of kidney stones.Urolithiasis · 2024Article
- Layered structure of sialoliths compared with tonsilloliths and antroliths.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2024Article
- Identification of biological components for sialolith formation organized in circular multi-layers.Scientific reports · 2023Article
- Application of metabolomics in urolithiasis: the discovery and usage of succinate.Signal transduction and targeted therapy · 2023Article
- Article
- Mechanisms of the intestinal and urinary microbiome in kidney stone disease.Nature reviews. Urology · 2022Review
- GeoBioMed perspectives on kidney stone recurrence from the reactive surface area of SWL-derived particles.Scientific reports · 2022Article
- Delineating the Role of the Urinary Metabolome in the Lithogenesis of Calcium-Based Kidney Stones.Urology · 2022Article
- Urinary stone composition in Germany: results from 45,783 stone analyses.World journal of urology · 2022Article
- How the diagnosis and the management of genetic renal phosphate leak impact the life of kidney stone formers?Urolithiasis · 2022Article
- Comparative functional analysis of the urinary tract microbiome for individuals with or without calcium oxalate calculi.Urolithiasis · 2022Article
- Liquid-Liquid Phase Separation in Nucleation Process of Biomineralization.Frontiers in chemistry · 2022Review
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17 authors at 9 institutions in 1 country.
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Abstract
More than 10% of the global human population is now afflicted with kidney stones, which are commonly associated with other significant health problems including diabetes, hypertension and obesity. Nearly 70% of these stones are primarily composed of calcium oxalate, a mineral previously assumed to be effectively insoluble within the kidney. This has limited currently available treatment options to painful passage and/or invasive surgical procedures. We analyze kidney stone thin sections with a combination of optical techniques, which include bright field, polarization, confocal and super-resolution nanometer-scale auto-fluorescence microscopy. Here we demonstrate using interdisciplinary geology and biology (geobiology) approaches that calcium oxalate stones undergo multiple events of dissolution as they crystallize and grow within the kidney. These observations open a fundamentally new paradigm for clinical approaches that include in vivo stone dissolution and identify high-frequency layering of organic matter and minerals as a template for biomineralization in natural and engineered settings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.