Evidence map›Paper›PMID 30213953›Full record

ArticleScientific reports2018

RNA-Seq Analysis of Spinal Cord Tissues from hPFN1

Caroline Barham, Daniel Fil, Stephanie D Byrum, Yasir Rahmatallah, Galina Glazko, Mahmoud Kiaei

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Profilin Isoforms in Health and Disease - All the Same but Different.Frontiers in cell and developmental biology · 2021
    Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Caroline BarhamDepartment of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID 0000-0002-8729-0383
Daniel FilDepartment of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Stephanie D ByrumDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Yasir RahmatallahDepartment of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Galina GlazkoDepartment of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Mahmoud KiaeiDepartment of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. MKiaei@UAMS.edu.ORCID 0000-0002-0802-1426
University of Arkansas for Medical Sciences · USUniversity of Alabama at Birmingham · USUniversity of Arkansas Medical Center · US

Funding

Understanding Hesitant AdoptersP20GM103429 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Lawrence E Cornett, JERRY WARE · 2012 to 2026
$60.9M
Translational Regulation in Normal Erythropoiesis and Diamond Blackfan AnemiaP20GM121293 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI Alan Tackett, Sean D. Taverna · 2017 to 2026
$27.6M
The Role o f Tetrahydrobiopterin (BH4) Bioavailability in Radiation-induced Skin InjuryP20GM109005 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI BOERMA, MARJAN · 2015 to 2024
$21.1M
Telemedicine CoreP30GM110702 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI GARCIA-RILL, EDGAR E. · 2014 to 2018
$6.1M
Development of a New ALS Mouse Model that Targets Profilin1 and Actin FilamentsR21NS088653 · NINDS · UNIV OF ARKANSAS FOR MED SCIS · PI KIAEI, MAHMOUD · 2015 to 2016
$410k
Alpha-Tubulin Mutation and Motor Neuron DiseaseR03NS101334 · NINDS · UNIV OF ARKANSAS FOR MED SCIS · PI KIAEI, MAHMOUD · 2017 to 2018
$149k
NIGMS NIH HHS P20 GM103429NIGMS NIH HHS P20 GM109005NIGMS NIH HHS P20 GM121293NIGMS NIH HHS P30 GM110702NINDS NIH HHS R03 NS101334NINDS NIH HHS R21 NS088653
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that leads to the loss of motor neurons. The molecular mechanisms of motor neuron degeneration are largely unknown and there are currently no effective therapies to treat this disease. In this work, we report whole transcriptome profiling of spinal cords of mutant transgenic hPFN1

Indexed as

Amyotrophic Lateral SclerosisAnimalsDisease Models, AnimalDisease ProgressionHumansMiceMice, TransgenicMotor NeuronsNeurodegenerative DiseasesNeurogliaProfilinsSequence Analysis, RNASpinal CordTranscriptomePFN1 protein, humanProfilins

Identifiers

PMID30213953
PMCPMC6137178
OpenAlexW2890027023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.