ArticleNature communications2018
Age structure landscapes emerge from the equilibrium between aging and rejuvenation in bacterial populations.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Article
- Lineage-dependent variations in single-cell antibiotic susceptibility reveal the selective inheritance of phenotypic resistance in bacteria.Nature communications · 2025Article
- A link between aging and persistence.Antimicrobial agents and chemotherapy · 2025Article
- Microfluidic biosensors for biomarker detection in body fluids: a key approach for early cancer diagnosis.Biomarker research · 2024Review
- Article
- Progressive decline in old pole gene expression signal enhances phenotypic heterogeneity in bacteria.Science advances · 2024Article
- Impact of Protein Aggregates on Sporulation and Germination ofMicroorganisms · 2023Article
- Expanding evolutionary theories of ageing to better account for symbioses and interactions throughout the Web of Life.Ageing research reviews · 2023Review
- Article
- Microfluidics for long-term single-cell time-lapse microscopy: Advances and applications.Frontiers in bioengineering and biotechnology · 2022Review
- Current Trends and Approaches to the Search for Genetic Determinants of Aging and Longevity.Russian journal of genetics · 2022Article
- Aging of Skeletal Stem Cells.Advances in geriatric medicine and research · 2022Article
- Long-time behavior and Darwinian optimality for an asymmetric size-structured branching process.Journal of mathematical biology · 2021Article
- Three-dimensional label-free visualization and quantification of polyhydroxyalkanoates in individual bacterial cell in its native state.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The role of memory in non-genetic inheritance and its impact on cancer treatment resistance.PLoS computational biology · 2021Article
- Survival of the first rather than the fittest in a Shewanella electrode biofilm.Communications biology · 2021Article
- Challenges of analysing stochastic gene expression in bacteria using single-cell time-lapse experiments.Essays in biochemistry · 2021Article
- Senescence in Bacteria and Its Underlying Mechanisms.Frontiers in cell and developmental biology · 2021Review
- Article
- Allocation of gene products to daughter cells is determined by the age of the mother in singleProceedings. Biological sciences · 2020Article
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Authors and funding
5 authors.
Funding
Abstract
The physiological asymmetry between daughters of a mother bacterium is produced by the inheritance of either old poles, carrying non-genetic damage, or newly synthesized poles. However, as bacteria display long-term growth stability leading to physiological immortality, there is controversy on whether asymmetry corresponds to aging. Here we show that deterministic age structure landscapes emerge from physiologically immortal bacterial lineages. Through single-cell microscopy and microfluidic techniques, we demonstrate that aging and rejuvenating bacterial lineages reach two distinct states of growth equilibria. These equilibria display stabilizing properties, which we quantified according to the compensatory trajectories of continuous lineages throughout generations. Finally, we show that the physiological asymmetry between aging and rejuvenating lineages produces complex age structure landscapes, resulting in a deterministic phenotypic heterogeneity that is neither an artifact of starvation nor a product of extrinsic damage. These findings indicate that physiological immortality and cellular aging can both be manifested in single celled organisms.
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