ArticleScience (New York, N.Y.)2018
Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers.
0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
152 citing papers in PubMed, 236 citations in OpenAlex.
- Calibrating T cell responsiveness through interactions with self.Nature reviews. Immunology · 2026Review
- Regulation of follicular helper T cell subset differentiation in health and disease.Journal of molecular medicine (Berlin, Germany) · 2026Review
- Bidirectional regulation by BACH2 coordinates systemic CXCR5- vs. CXCR5+ CD4+ T cell differentiation.The Journal of experimental medicine · 2026Article
- TGF-β and IL-2 differentially shape T follicular regulatory cell differentiation and stability in vitro.Cellular & molecular immunology · 2026Article
- A Case for Anti-IgE Vaccination.Allergy · 2026Review
- A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation.The Journal of experimental medicine · 2026Article
- IL-2 silencing enables Tfh cell expansion during vaccination but is redundant for antibody production.Immunology and cell biology · 2026Article
- The MEK1/2-IRF4 axis fosters T follicular helper cell differentiationand antitumor humoral immune response.Journal of translational medicine · 2026Article
- An early burst of cytokine production before the first cell division influences CD8 T cell differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Dendritic Cell Organization and Function in Innate and Adaptive Immune Defense Within Lymph Nodes.Immunological reviews · 2026Review
- Pre-Existing Th1 Immunity Outperforms Age in Predicting Antibody Responses to SARS-CoV-2 Inactivated Vaccines.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Review
- Functional Specialization and Collaboration of cDC2 Subsets in CD4+ T Cell Priming and Differentiation.Immunological reviews · 2025Review
- Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity.Nature immunology · 2025Article
- Role of the Th2-like Immune Response in Obesity: IL-4 as a Metabolic Regulator and IL-13 as an Effector of Muscle Energy Metabolism.Biomedicines · 2025Review
- Tissue-Resident T Cells That Promote Humoral Immunity: Emerging From the Shadow of T Follicular Helper Cells.Immunological reviews · 2025Review
- Integration of phospho-signaling and transcriptomics in single cells reveals distinct Th17 cell fates.Cell reports · 2025Article
- BLIMP1 negatively regulates IL-2 signaling in T cells.Science advances · 2025Article
- T follicular helper 1 cells in blood potentially mirror salivary gland-infiltrating T cells in Sjögren's disease.Scientific reports · 2025Article
- KMT2D coordinates antiviral CD4Cell reports · 2025Article
92 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 5 institutions in 2 countries.
Daniel DiToroDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35203, USA.
Colleen J WinsteadDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35203, USA.
Duy PhamDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35203, USA.ORCID 0000-0003-1367-6643
Steven WitteDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35203, USA.ORCID 0000-0001-6240-4615
Rakieb AndargachewDepartment of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0003-1541-4874
Jeffrey R SingerDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35203, USA.ORCID 0000-0001-7033-3001
C Garrett WilsonDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35203, USA.
Carlene L ZindlDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35203, USA.
Rita J LutherDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35203, USA.ORCID 0000-0002-2836-7125
Daniel J SilbergerDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35203, USA.
Benjamin T WeaverHudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA.
E Motunrayo KolawoleDepartment of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.
Ryan J MartinezDepartment of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.
Henrietta TurnerDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35203, USA.
Robin D HattonDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35203, USA.ORCID 0000-0002-4797-9899
James J MoonCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.ORCID 0000-0001-8246-931X
Sing Sing WayDivision of Infectious Diseases and Perinatal Institute, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA.
Brian D EvavoldDepartment of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-3561-3494
Casey T WeaverDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35203, USA. cweaver@uab.edu.ORCID 0000-0002-2180-1793
University of Alabama at Birmingham · USEmory University · USCincinnati Children's Hospital Medical Center · USHarvard University · USHudsonAlpha Institute for Biotechnology · US
Funding
XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MICHAEL JAMES BERTRAM · 1985 to 2026
$165.9MPilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MMEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3MMEDICAL SCIENTIST TRAINING PROGRAMT32GM008361 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YACOUBIAN, TALENE ALENE · 1992 to 2024
$16.8MIMMUNOLOGIC DISEASES AND BASIC IMMUNOLOGYT32AI007051 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Laurie Ellen Harrington · 1985 to 2026
$13.1MImmunological identity redefined by genetically foreign microchimeric cellsDP1AI131080 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI WAY, SING SING · 2016 to 2020
$5.5MPOSTTHYMIC T-CELL FUNCTIONAL REPERTOIRE HETEROGENEITYR01AI035783 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WEAVER, CASEY T · 1994 to 2010
$2.4MSpecialization of Innate and Adaptive Immune Cells in Intestinal Barrier FunctionR01DK113789 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WEAVER, CASEY T · 2017 to 2021
$2.3MSelf Antigen Specific CD4 Positive T cellsR01AI107020 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MOON, JAMES J · 2014 to 2018
$2.1MMaternal Regulatory T cell antigen-specificityR01AI120202 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI WAY, SING SING · 2016 to 2020
$1.9MFunctional immune tolerance to non-inherited maternal antigenR01AI124657 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI WAY, SING SING · 2017 to 2021
$1.9M2D affinity and frequency of antigen specific TregsR01AI110113 · NIAID · UNIVERSITY OF UTAH · PI EVAVOLD, BRIAN D · 2015 to 2019
$1.9MNCI NIH HHS P30 CA013148NIAID NIH HHS DP1 AI131080NIAID NIH HHS R01 AI035783NIAID NIH HHS R01 AI057956NIAID NIH HHS R01 AI077574NIAID NIH HHS R01 AI107020NIAID NIH HHS R01 AI110113NIAID NIH HHS R01 AI120202NIAID NIH HHS R01 AI124657NIAID NIH HHS R21 AI035783NIAID NIH HHS R21 AI124143NIAID NIH HHS T32 AI007051NIDDK NIH HHS F30 DK105680NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R01 DK113789NIGMS NIH HHS T32 GM008169NIGMS NIH HHS T32 GM008361
Abstract
In response to infection, naïve CD4
Indexed as
Gene ExpressionAnimalsCD4-Positive T-LymphocytesChromatinGenes, ReporterInterleukin-2Lymphocyte ActivationMiceMice, TransgenicProto-Oncogene Proteins c-bcl-2Receptors, Antigen, T-CellT-Lymphocytes, Helper-InducerTranscription FactorsBcl2 protein, mouseChromatinInterleukin-2Proto-Oncogene Proteins c-bcl-2Receptors, Antigen, T-CellTranscription Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.