Evidence map›Paper›PMID 30213867›Full record

ArticleG3 (Bethesda, Md.)2018

A

Nhan Huynh, Jie Zeng, Wen Liu, Kirst King-Jones

Abstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. A Landscape ofBiology · 2026
    Review
  2. Article
  3. Embedded CRISPRi Enhances Gene-Silencing Efficiency in Drosophila.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. 20E-inducedProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. tsCRISPR based identification of Rab proteins required for the recycling ofFrontiers in cell and developmental biology · 2024
    Article
  8. Article
  9. Tissue-specific knockout inbioRxiv : the preprint server for biology · 2023
    Article
  10. Endoreplication in themicroPublication biology · 2023
    Article
  11. Review
  12. Precise genome engineering inProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nhan HuynhDepartment of Biological Sciences, Faculty of Science, University of Alberta, G-502 Biological Sciences Bldg, Edmonton, Alberta T6G 2E9, Canada.
Jie ZengDepartment of Biological Sciences, Faculty of Science, University of Alberta, G-502 Biological Sciences Bldg, Edmonton, Alberta T6G 2E9, Canada.
Wen LiuDepartment of Biological Sciences, Faculty of Science, University of Alberta, G-502 Biological Sciences Bldg, Edmonton, Alberta T6G 2E9, Canada.ORCID 0000-0002-4985-0618
Kirst King-JonesDepartment of Biological Sciences, Faculty of Science, University of Alberta, G-502 Biological Sciences Bldg, Edmonton, Alberta T6G 2E9, Canada kingjone@ualberta.ca.ORCID 0000-0002-9089-8015

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeting gene function with spatial or temporal specificity is a key goal in molecular genetics. CRISPR-Cas9 has greatly facilitated this strategy, but some standard approaches are problematic. For instance, simple tissue-specific or global overexpression of Cas9 can cause significant lethality or developmental delays even in the absence of gRNAs. In particular, we found that Gal4-mediated expression of UAS-Cas9 in the

Indexed as

AnimalsCRISPR-Cas SystemsCytochrome P-450 Enzyme SystemDrosophilaDrosophila ProteinsExocrine GlandsGene Expression RegulationMixed Function OxygenasesCytochrome P-450 Enzyme SystemDIB protein, DrosophilaDrosophila ProteinsMixed Function OxygenasesPhm protein, DrosophilaCRISPR/CAS9ecdysoneendoreplicationHalloween genespolytene tissueprothoracic glandsteroid hormone

Identifiers

PMID30213867
PMCPMC6222582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.