Evidence map›Paper›PMID 30213858›Full record

ArticleThe Journal of biological chemistry2018

CatSper channels are regulated by protein kinase A.

Gerardo Orta, José Luis de la Vega-Beltran, David Martín-Hidalgo, Celia M Santi, Pablo E Visconti, Alberto Darszon

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
9.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. Regulation of spermatozoal capacitation by serotonin.The Journal of reproduction and development · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Dynamic relocation of PKA regulatory subunits during sperm capacitation: Linking PKA to the CatSper signaling complex.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Enhancement of rat spermatozoal hyperactivation by progesterone.The Journal of reproduction and development · 2023
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Gerardo OrtaFrom the Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Morelos 62250, México.
José Luis de la Vega-BeltranFrom the Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Morelos 62250, México.
David Martín-HidalgoDepartment of Veterinary and Animal Science, Integrated Sciences Building, University of Massachusetts, Amherst, Massachusetts 01003, and.ORCID 0000-0002-6787-0006
Celia M SantiDepartment of Obstetrics and Gynecology and.
Pablo E ViscontiDepartment of Veterinary and Animal Science, Integrated Sciences Building, University of Massachusetts, Amherst, Massachusetts 01003, and pvisconti@vasci.umass.edu.
Alberto DarszonFrom the Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Morelos 62250, México, darszon@ibt.unam.mx.ORCID 0000-0002-2502-0505
Universidad Nacional Autónoma de México · MXUniversity of Massachusetts Amherst · USWashington University in St. Louis · US

Funding

Sperm Ca2+ Signaling and Energy Pathways in basic science and ARTR01HD038082 · NICHD · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI VISCONTI, PABLO E. · 2000 to 2025
$6.5M
NICHD NIH HHS R01 HD038082
6 · The paper itself

Abstract

Mammalian sperm must undergo capacitation as a preparation for entering into hyperactivated motility, undergoing the acrosome reaction, and acquiring fertilizing ability. One of the initial capacitation events occurs when sperm encounter an elevated HCO

Indexed as

AnimalsCalciumCalcium ChannelsCell MembraneCyclic AMP-Dependent Protein KinasesMaleMicePhosphorylationSpermatozoaSperm CapacitationSperm MotilityCalciumCalcium ChannelsCatsper1 protein, mouseCyclic AMP-Dependent Protein KinasesAMPcalciumcalcium channelcalcium imagingcAMPcapacitationCatSper cation channelelectrophysiologymale fertilityprotein kinase A (PKA)reproductive biologyspermsperm motility

Identifiers

PMID30213858
PMCPMC6204891
OpenAlexW2890638737

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.