Evidence map›Paper›PMID 30213853›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors.

Hardeep P Singh, Sijia Wang, Kevin Stachelek, Sunhye Lee, Mark W Reid, Matthew E Thornton, Cheryl Mae Craft, Brendan H Grubbs, David Cobrinik

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. The trends of retinoblastoma research in the past decade.International journal of ophthalmology · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Retinoma: An overview.Pediatric investigation · 2025
    Review
  10. Article
  11. Article
  12. Tissue Engineering and Ophthalmology.Turkish journal of ophthalmology · 2024
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Sunitinib efficacy with minimal toxicity in patient-derived retinoblastoma organoids.Journal of experimental & clinical cancer research : CR · 2023
    Article
  20. ADAM10 and ADAM17-Novel Players in Retinoblastoma Carcinogenesis.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hardeep P SinghThe Vision Center, Children's Hospital Los Angeles, Los Angeles, CA 90027.
Sijia WangThe Vision Center, Children's Hospital Los Angeles, Los Angeles, CA 90027.
Kevin StachelekThe Vision Center, Children's Hospital Los Angeles, Los Angeles, CA 90027.
Sunhye LeeThe Vision Center, Children's Hospital Los Angeles, Los Angeles, CA 90027.
Mark W ReidThe Vision Center, Children's Hospital Los Angeles, Los Angeles, CA 90027.
Matthew E ThorntonMaternal-Fetal Medicine Division of the Department of Obstetrics and Gynecology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033.
Cheryl Mae CraftUSC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033.
Brendan H GrubbsMaternal-Fetal Medicine Division of the Department of Obstetrics and Gynecology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033.
David CobrinikThe Vision Center, Children's Hospital Los Angeles, Los Angeles, CA 90027; dcobrinik@chla.usc.edu.ORCID 0000-0002-4478-2417
University of Southern California · USChildren's Hospital of Los Angeles · US

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4M
Successive responses to oncogenic aberrations in retinoblastoma genesis.R01CA137124 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI David Cobrinik · 2011 to 2026
$6.3M
NCI NIH HHS P30 CA014089NCI NIH HHS R01 CA137124
6 · The paper itself

Abstract

Most retinoblastomas initiate in response to the inactivation of the

Indexed as

Cell DivisionS PhaseAnimalsHumansMiceMice, KnockoutRetinal Cone Photoreceptor CellsRetinal NeoplasmsRetinoblastomaRetinoblastoma ProteinSpecies SpecificityRetinoblastoma Proteincancer cell of origincone photoreceptorgenetically engineered mouse modelsretinoblastomaretinoma

Identifiers

PMID30213853
PMCPMC6176579
OpenAlexW2950626489

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.