ArticleAJNR. American journal of neuroradiology2018
Automated Integration of Multimodal MRI for the Probabilistic Detection of the Central Vein Sign in White Matter Lesions.
Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- The "Central Vein Sign" on T2*-weighted Images as a Diagnostic Tool in Multiple Sclerosis: A Systematic Review and Meta-analysis using Individual Patient Data.Scientific reports · 2019Pooled it
- Conventional and Advanced Magnetic Resonance Imaging Biomarkers of Multiple Sclerosis in the Brain.Cureus · 2025Review
- Automated segmentation of multiple sclerosis lesions, paramagnetic rims, and central vein sign on MRI provides reliable diagnostic biomarkers.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Diagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Article
- Current and future role of MRI in the diagnosis and prognosis of multiple sclerosis.The Lancet regional health. Europe · 2024Review
- Central Vein Sign and Paramagnetic Rim Lesions: Susceptibility Changes in Brain Tissues and Their Implications for the Study of Multiple Sclerosis Pathology.Diagnostics (Basel, Switzerland) · 2024Review
- A multicenter pilot study evaluating simplified central vein assessment for the diagnosis of multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Article
- The use of 7T MRI in multiple sclerosis: review and consensus statement from the North American Imaging in Multiple Sclerosis Cooperative.Brain communications · 2024Review
- Present and future of the diagnostic work-up of multiple sclerosis: the imaging perspective.Journal of neurology · 2023Review
- Neurodegeneration in multiple sclerosis.WIREs mechanisms of disease · 2023Review
- Lesion size and shape in central vein sign assessment for multiple sclerosis diagnosis: An in vivo and postmortem MRI study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Central vein sign: A diagnostic biomarker in multiple sclerosis (CAVS-MS) study protocol for a prospective multicenter trial.NeuroImage. Clinical · 2021Article
- Intensity warping for multisite MRI harmonization.NeuroImage · 2020Article
- The Use of the Central Vein Sign in the Diagnosis of Multiple Sclerosis: A Systematic Review and Meta-analysis.Diagnostics (Basel, Switzerland) · 2020Review
- Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study.Annals of neurology · 2020Article
- CVSnet: A machine learning approach for automated central vein sign assessment in multiple sclerosis.NMR in biomedicine · 2020Article
- Detection of central vein should be part of MS diagnostic criteria - Commentary.Multiple sclerosis (Houndmills, Basingstoke, England) · 2020Article
- Assessment of lesions on magnetic resonance imaging in multiple sclerosis: practical guidelines.Brain : a journal of neurology · 2019Review
- The Central Vein Sign in Radiologically Isolated Syndrome.AJNR. American journal of neuroradiology · 2019Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
background and purposeThe central vein sign is a promising MR imaging diagnostic biomarker for multiple sclerosis. Recent studies have demonstrated that patients with MS have higher proportions of white matter lesions with the central vein sign compared with those with diseases that mimic MS on MR imaging. However, the clinical application of the central vein sign as a biomarker is limited by interrater differences in the adjudication of the central vein sign as well as the time burden required for the determination of the central vein sign for each lesion in a patient's full MR imaging scan. In this study, we present an automated technique for the detection of the central vein sign in white matter lesions. MATERIALS AND
methodsUsing multimodal MR imaging, the proposed method derives a central vein sign probability, π
resultsBy means of the proposed automated technique, participants with MS were found to have significantly higher values of ψ than those without MS (ψ
conclusionsThe current study presents the first fully automated method for detecting the central vein sign in white matter lesions and demonstrates promising performance in a sample of patients with and without MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.