Evidence map›Paper›PMID 30213800›Full record

ArticleJournal of lipid research2018

Cholesterol efflux responds to viral load and CD4 counts in HIV+ patients and is dampened in HIV exposed.

Olivia Tort, Tuixent Escribà, Lander Egaña-Gorroño, Elisa de Lazzari, Montserrat Cofan, Emma Fernandez, José Maria Gatell, Esteban Martinez, Felipe Garcia, Mireia Arnedo

Open access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Olivia TortGroup of Genomics and Pharmacogenomics, Acquired Immune Deficiency Syndrome Research Group, Catalan Project for the Development of a Human Immunodeficiency Virus Vaccine (HIVACAT), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain.
Tuixent EscribàGroup of Genomics and Pharmacogenomics, Acquired Immune Deficiency Syndrome Research Group, Catalan Project for the Development of a Human Immunodeficiency Virus Vaccine (HIVACAT), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain.
Lander Egaña-GorroñoGroup of Genomics and Pharmacogenomics, Acquired Immune Deficiency Syndrome Research Group, Catalan Project for the Development of a Human Immunodeficiency Virus Vaccine (HIVACAT), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain.
Elisa de LazzariInfectious Diseases Service, Hospital Clínic-IDIBAPS, Laboratory of Retrovirology and Viral Immunopathogenesis, University of Barcelona, Barcelona, Spain.
Montserrat CofanLipid Clinic, Department of Endocrinology and Nutrition, Hospital Clínic de Barcelona, IDIBAPS, Barcelona, Spain and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Emma FernandezInfectious Diseases Service, Hospital Clínic-IDIBAPS, Laboratory of Retrovirology and Viral Immunopathogenesis, University of Barcelona, Barcelona, Spain.
José Maria GatellHospital Clinic/IDIBAPS, University of Barcelona, ViiV Healthcare, Barcelona, Spain.
Esteban MartinezInfectious Diseases Service, Hospital Clínic-IDIBAPS, Laboratory of Retrovirology and Viral Immunopathogenesis, University of Barcelona, Barcelona, Spain.
Felipe GarciaInfectious Diseases Service, Hospital Clínic-IDIBAPS, Laboratory of Retrovirology and Viral Immunopathogenesis, University of Barcelona, Barcelona, Spain.
Mireia ArnedoGroup of Genomics and Pharmacogenomics, Acquired Immune Deficiency Syndrome Research Group, Catalan Project for the Development of a Human Immunodeficiency Virus Vaccine (HIVACAT), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain marnedo@clinic.cat.
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESHospital Clínic de Barcelona · ESUniversitat de Barcelona · ESInstituto de Salud Carlos III · ESViiV Healthcare (Spain) · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholesterol efflux (CE) capacity has been inversely associated with atherosclerosis and may provide an insight on inflammation occurring in human immunodeficiency virus (HIV) individuals. We address this by studying CE in HIV patients at different stages of HIV disease progression. In this cross-sectional study, CE from ApoB-depleted plasma, lipids levels, viral load (VL), CD4+/CD8+ T-cells, high-sensitive C-reactive protein (hsCRP), and lipoprotein (a) were evaluated in untreated HIV-infected patients (UHIVs; n = 43), elite controllers (ECs; n = 8), HIV-exposed seronegative individuals (HESNs; n = 32), and healthy controls (HCs; n = 14). Among UHIVs, those with CD4+ <500 cells/mm

Indexed as

AdultBiological TransportCD4 Lymphocyte CountCholesterolCholesterol, HDLCross-Sectional StudiesFemaleHIV-1HIV InfectionsHomosexuality, MaleHumansMaleMiddle AgedViral LoadCholesterolCholesterol, HDLapolipoprotein AIcardiovascular diseaseCD4+ T-cellhigh density lipoprotein cholesterolhuman immunodeficiency virus-exposed seronegativehuman immunodeficiency virus-infectedlipoprotein (a)

Identifiers

PMID30213800
PMCPMC6210904
OpenAlexW2889734788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.