ReviewNeurobiology of disease2019
Dichotomy between motor and cognitive functions of midbrain cholinergic neurons.
Review in Neurobiology of disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Neuroanatomical and clinical correlates of prodromal dementia with Lewy bodies: a systematic literature review of neuroimaging findings.Journal of neurology · 2024Pooled it
- Cell-type specific sensory and motor activity in the cuneiform nucleus and pedunculopontine nucleus in mice.Scientific reports · 2025Article
- Motor-Cognitive Dual-Task Cost and Associated Micro Lesions of Cerebellum and Brainstem in Multiple System Atrophy (Parkinsonian Type).Cerebellum (London, England) · 2025Article
- Modulating the cholinergic system-Novel targets for deep brain stimulation in Parkinson's disease.Journal of neurochemistry · 2025Review
- Sequential patterning of dynamic brain states distinguish Parkinson's disease patients with mild cognitive impairments.NeuroImage. Clinical · 2025Article
- Brain atrophy and cholinergic denervation in progressive supranuclear palsy: an MRI and [Frontiers in neuroscience · 2025Article
- The Mesencephalic Locomotor Region: Multiple Cell Types, Multiple Behavioral Roles, and Multiple Implications for Disease.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Dopamine-sensitive neurons in the mesencephalic locomotor region control locomotion initiation, stop, and turns.Cell reports · 2024Article
- Neurodevelopmental outcome in preterm infants with intraventricular hemorrhages: the potential of quantitative brainstem MRI.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Free-water imaging of the cholinergic basal forebrain and pedunculopontine nucleus in Parkinson's disease.Brain : a journal of neurology · 2023Article
- Progression of regional cortical cholinergic denervation in Parkinson's disease.Brain communications · 2022Article
- Cholinergic systems, attentional-motor integration, and cognitive control in Parkinson's disease.Progress in brain research · 2022Review
- Laterodorsal tegmentum-ventral tegmental area projections encode positive reinforcement signals.Journal of neuroscience research · 2021Article
- Whole-brain mapping of monosynaptic inputs to midbrain cholinergic neurons.Scientific reports · 2021Article
- Effect of ciliary neurotrophic factor on neural differentiation of stem cells of human exfoliated deciduous teeth.Journal of biological engineering · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cholinergic neurons of the pedunculopontine nucleus (PPN) are interconnected with all the basal ganglia structures, as well as with motor centers in the brainstem and medulla. Recent theories put into question whether PPN cholinergic neurons form part of a locomotor region that directly regulates the motor output, and rather suggest a modulatory role in adaptive behavior involving both motor and cognitive functions. In support of this, experimental studies in animals suggest that cholinergic neurons reinforce actions by signaling reward prediction and shape adaptations in behavior during changes of environmental contingencies. This is further supported by clinical studies proposing that decreased cholinergic transmission originated in the PPN is associated with impaired sensorimotor integration and perseverant behavior, giving rise to some of the symptoms observed in Parkinson's disease and progressive supranuclear palsy. Altogether, the evidence suggests that cholinergic neurons of the PPN, mainly through their interactions with the basal ganglia, have a leading role in action control.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.